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Comparison of the trometamol-balanced solution with two other crystalloid solutions for fluid resuscitation of a rat hemorrhagic model

Journal of Veterinary Science 2020년 21권 1호 p.6 ~ 6
 ( Ting Wen-Ting ) - National Taiwan University National Taiwan University Hospital Department of Surgery

 ( Chang Ru-Wen ) - National Taiwan University National Taiwan University Hospital Department of Surgery
 ( Wang Chih-Hsien ) - National Taiwan University National Taiwan University Hospital Department of Surgery
 ( Chen Yih-Sharng ) - National Taiwan University National Taiwan University Hospital Department of Surgery
이지종 ( Lee Jih-Jong ) - National Taiwan University School of Veterinary Medicine

Abstract


Currently, the optimal resuscitation fluid remains debatable. Therefore, in the present study, we designed a trometamol-balanced solution (TBS) for use as a resuscitation fluid for hemorrhagic shock. Hemorrhagic shock was induced in 18 male Wistar-Kyoto rats, which were assigned to normal saline (NS), Ringer's solution (RS), and TBS groups. During the hemorrhagic state, their hemodynamic parameters were recorded using an Abbott i-STAT analyzer with the CG4+ cartridge (for pH, pressure of carbon dioxide, pressure of oxygen, total carbon dioxide, bicarbonate, base excess, oxygen saturation, and lactate), the CG6+ cartridge (for sodium, potassium, chloride, blood glucose, blood urea nitrogen, hematocrit, and hemoglobin), and enzyme-linked immunosorbent assay kits (calcium, magnesium, creatinine, aspartate aminotransferase, alanine aminotransferase, bilirubin, and albumin). Similar trends were found for the parameters of biochemistries, electrolytes, and blood gas, and they revealed no significant changes after blood withdrawal-induced hemorrhagic shock. However, the TBS group showed more effective ability to correct metabolic acidosis than the NS and RS groups. TBS was a feasible and safe resuscitation solution in this study and may be an alternative to NS and RS for resuscitation in hemorrhagic shock patients without liver damage.

키워드

Resuscitation fluid; normal saline; Ringer's solution; hemorrhagic model
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