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Interleukin-8 (IL-8) Expression in the Olive Flounder (Paralichthys olivaceus) against Viral Hemorrhagic Septicemia Virus (VHSV) Challeng

발생과생식 2019년 23권 3호 p.231 ~ 238
 ( Kim Kyung-Hee ) - National Institute of Fisheries Science Genetics and Breeding Research Center

 ( Kim Hyun-Chul ) - National Institute of Fisheries Science Genetics and Breeding Research Center
 ( Park Choul-Ji ) - National Institute of Fisheries Science Genetics and Breeding Research Center
 ( Park Jong-Won ) - National Institute of Fisheries Science Genetics and Breeding Research Center
 ( Lee Young-Mee ) - National Institute of Fisheries Science Genetics and Breeding Research Center
 ( Kim Woo-Jin ) - National Institute of Fisheries Science Genetics and Breeding Research Center

Abstract


Interleukin-8 (IL-8) is an inflammatory cytokine that plays an important role in the inflammatory response through the activation of neutrophil cells. The expression of IL-8 was investigated in early developmental stages of the olive flounder and in tissues of 8-month-old individuals. The expression of IL-8 increased after the initiation of the immune system rather than at the early stage of development, and high expression was observed in the gills and spleen, the organs associated with immunity and metabolism. In addition, IL-8 expression after infection by viral hemorrhagic septicemia virus significantly increased in the fin, gill, muscles, and spleen. These results suggest that IL-8 is closely related to inflammation and immune regulation in the immune response of the olive flounder and may be used as a basis for studies on the immune systems of other fish.

키워드

Olive flounder Paralichthys olivaceus; Gene expression; Interleukin-8 (IL-8); Viral hemorrhagic septicemia virus (VHSV)
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