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에스트로겐이 결핍된 흰쥐에서 한약혼합물이 비만 관련 호르몬에 미치는 영향

Effects of Herbal Prescription on Obesity Related Hormones in Rats with Estrogen Deficiency

한방재활의학과학회지 2020년 30권 1호 p.1 ~ 12
박정식 ( Park Jung-Sik ) - 가천대학교 한의과대학

임정설 ( Lim Jeung-Seol ) - 가천대학교 한의과대학
임형호 ( Lim Hyung-Ho ) - 가천대학교 한의과대학
황귀서 ( Hwang Gwi-Seo ) - 가천대학교 한의과대학

Abstract


Objectives : Depletion of ovarian function after menopause in women induces estrogen deficiency leading to increased fat and decreased muscle mass. In this study, we examined the effect of herbal medicines by measuring hormone expression in muscle tissue of estrogen-deficient rats induced by ovariectomy.

Methods : Ovariectomy was performed to induce estrogen deficiency, and mice were given herbal prescription (HP) for 6 weeks. Estrogen-deficient rats were divided into two groups: one group (HPH) which were orally administered HP 200 mg/kg and the other group (HPL) administered HP 40 mg/kg. Weight changes in both groups were measured using polymerase chain reaction (PCR). After extraction of the femoral muscles in mice, the expression of the leptin, lipoprotein lipase (LPL), diacyl glycerol acyltransferase (DGAT)1, peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α, NADH dehydrogenase (NDH), farnesyl diphosphate farnesyltransferase (FDFT)1, lanosterol synthase (LSS), phosphatidylethanolamine N-methyltransferase (PEMT), and peroxiredoxin (Prdx6) were measured using PCR.

Results : HP increased the expression of leptin, LPL, DGAT1, PGC-1α, NDH, FDFT1, LSS, PEMT, and Prdx6. HP affects body fat metabolism and is effective in improving menopausal obesity and obesity complications caused by estrogen deficiency. However, HP does not affect the expression of tumor necrosis factor-α and 3-hydroxy-3-methylglutaryl-CoA reductase, and thus will not be effective in obesity-related metabolic diseases.

Conclusions : HP is thought to inhibit weight gain by regulating hormone expression related to glucose metabolism and lipid metabolism in muscle tissue of estrogen-deficient rats.

키워드

Obesity; Estrogens; Herbal medicine
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