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좌골신경통 백서모델에서 침치료의 효과: 체계적 문헌고찰 및 메타분석

Effect of Acupuncture on Sciatica in Rat Models: Systematic Review and Meta-analysis

한방재활의학과학회지 2020년 30권 1호 p.79 ~ 93
윤예지 ( Yoon Ye-Ji ) - 강동경희대학교한방병원 한방재활의학과

김수전 ( Kim Soo-Jeon ) - 강동경희대학교한방병원 한방재활의학과
조재흥 ( Cho Jae-Heung ) - 경희대학교 한의과대학 한방재활의학과교실
김고운 ( Kim Koh-Woon ) - 경희대학교 한의과대학 한방재활의학과교실
송미연 ( Song Mi-Yeon ) - 경희대학교 한의과대학 한방재활의학과교실

Abstract


Objectives : While sciatic neuropathy is one of the common symptoms which have the lifetime incidence of 13~40%, still there is no consensus about the standardized and the most effective conservative treatment. In addition, the importance of systematic review and meta-analysis of preclinical are growing as they could suggest possible effective treatment strategy for future studies. Therefore, we conducted systematic review and meta-analysis to estimate analgesic effect of acupuncture on sciatica in rat models.

Methods : Systematic search was conducted for all controlled comparative preclinical trials which assessed analgesic effect of acupuncture in sciatica rat models. Database of PubMed, EMBASE, Web of Science, CNKI and 6 Korean databases were used. The primary outcome was pain, which is evaluated by stimulus behavior tests in rat models. We assessed the methodological quality with Systematic Review Centre for Laboratory Animal Experimentation’s risk of bias tool. RevMan 5.3 was used for meta-analysis and subgroup analysis was conducted according to treatment site, acupuncture point, treatment period and frequency used in electroacupuncture.

Results : 14 studies were finally included following our inclusion criteria. The data from meta-analysis indicated that the acupuncture significantly improved the result values of behavior tests for pain evaluation, compared to no-treatment control group in animal models (standardized mean difference=4.43, 95% confidence interval 3.16 to 5.69, Z=6.84, p<0.00001; χ2=68.02, p<0.00001; I2=82%). The results of subgroup analysis indicate that acupuncture treatment of unilateral site, distal acupoints, longer treatment period and applying 2/100 Hz frequency in electroacupuncture could be more effective.

Conclusions : Systematic review and meta-analysis of animal studies are getting important for the future clinical studies and the improvement of heatlh care. Therefore the results of the study would provide evidence and better design for the forthcoming studies.

키워드

Sciatica; Acupuncture; Electroacupuncture; Animal model; Systematic review; Meta analysis
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