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Does Caffeine Trigger Migraine Attack? A Smartphone Headache Diary Study

두통 2019년 20권 2호 p.22 ~ 27
김현석 ( Kim Hyun-Suk ) - 가천대학교 의과대학 길병원 신경과학교실

배기환 ( Pae Kee-Hwan ) - 가천대학교 의과대학 예방의학교실
신동진 ( Shin Dong-Jin ) - 가천대학교 의과대학 길병원 신경과학교실
박현미 ( Park Hyeon-Mi ) - 가천대학교 의과대학 길병원 신경과학교실
최석홍 ( Choi Seok-Hong ) - 가천대학교 의과대학 길병원 신경과학교실
이현준 ( Lee Hyun-Joon ) - 가천대학교 의과대학 길병원 신경과학교실
김두환 ( Kim Du-Hwan ) - 가천대학교 의과대학 길병원 신경과학교실
정재훈 ( Chung Jae-Hoon ) - 가천대학교 의과대학 예방의학교실
은성종 ( Eun Sung-Jong ) - 가천대학교 컴퓨터공학과
주민경 ( Chu Min-Kyung ) - 연세대학교 의과대학 세브란스병원 신경과학교실
신동훈 ( Shin Dong-Hoon ) - 가천대학교 의과대학 길병원 신경과학교실

Abstract


Background: Migraine is common neurological condition in developed countries. The role of caffeine in migraine has been not established yet. Mobile applications are more useful than paper diary because they can increase patient compliance. Therefore, we tried to investigate the relation between intake of caffeine and the occurrence of
a migraine attack using a smartphone electronic headache diary.

Methods: We enrolled 77 patients with migraine and conducted a prospective cross-sectional study. We used the
smartphone headache diary to capture the details regarding caffeine intake, and headache occurrence. We investigated
the association between caffeine intake and headache occurrence at every day based on daily records of
smartphone headache diary.

Results: We analyzed the data of 49 patients who completed more than 16 attacks of headache. Headaches have
occurred in average of 24.1 during application working day. The mean duration of recoding headache diary
was 181.1±126.2 days, and the average number of days in which the patient actually wrote the headache diary
was 118.4±108.2 days. Caffeine intake was significantly associated with migraine attack (OR for migraine attack=
1.4, 95% CI, 1.2-1.6, p<0.001) after adjustment of age and sex. Among migraine attacks with moderate-to-severe
headache intensity, migraine attacks were significantly associated with caffeine intake after adjusting covariates
(OR=1.4, 95% CI, 1.1-1.7, p=0.002).

Conclusion: Caffeine intake was significantly associated with headache attack among migraineurs. Smartphone
headache diary application is an effective tool to assess and study migraine.

키워드

Caffeine; Migraine; Triptans; Mobile applications; Smartphone
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