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Antiviral Activity of Gemcitabine Against Echovirus 30 Infection in Vitro

Journal of Bacteriology and Virology 2019년 49권 4호 p.203 ~ 211
최화정 ( Choi Hwa-Jung ) - Kwangju Women’s University Department of Beauty Science

송재형 ( Song Jae-Hyoung ) - Kangwon National University College of Pharmacy
 ( Yoon Kyung-Ah ) - Daejeon Health Institute of Technology Department of Clinical Pathology

Abstract


Echovirus 30 is one of the major causes of meningitis in children and adults. The purpose of our current study was to investigate whether selected antiviral drugs could provide antiviral activity against echovirus 30. Using RD cells, we assessed the cytopathic effect of echovirus 30, including viral RNA levels as indicators of viral replication. The effects of gemcitabine were compared to rupintrivir, a well-known antiviral drug. To understand the activity gemcitabine exerts on the viral life cycle, time course and time-of-addition assays were implemented. The most effective compounds against echovirus 30 were gemcitabine and rupintrivir, as demonstrated by their concentration-dependent activity. Gemcitabine affects the early stages of echovirus 30 infection by disrupting viral replication. However, gemcitabine failed to directly inactivate echovirus 30 particles or impede viral uptake into the RD cells. Gemcitabine can be considered as a lead candidate in the development of echovirus 30 antiviral drugs, specifically in the early stages of echovirus 30 replication.

키워드

Echovirus 30; Gemcitabine; Early stages
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