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Downregulation of IL-18 Expression in the Gut by Metformin-induced Gut Microbiota Modulation

Immune Network 2019년 19권 4호 p.28 ~ 28
 ( Lee Hee-Tae ) - Sahmyook University College of Pharmacy

 ( Kim Ji-Yeon ) - Sahmyook University College of Pharmacy
 ( An Jin-Ho ) - Sahmyook University College of Pharmacy
 ( Lee Sung-Won ) - Sahmyook University College of Pharmacy
 ( Choi Do-Hyun ) - Sahmyook University College of Pharmacy
 ( Kong Hyun-Seok ) - Sahmyook University College of Pharmacy
 ( Song Young-Cheon ) - Sahmyook University College of Pharmacy
 ( Park Il-Ho ) - Sahmyook University College of Pharmacy
 ( Lee Chong-Kil ) - Chungbuk National University College of Pharmacy
 ( Kim Kyung-Jae ) - Sahmyook University College of Pharmacy

Abstract


IL-18 is a crucial pro-inflammatory cytokine that mediates chronic intestinal inflammation. Metformin, an anti-diabetic drug, was reported to have ameliorative effects on inflammatory bowel disease. Recently, the mechanism of action of metformin was explained as a modulation of gut microbiota. In this study, fecal microbiota transplantation (FMT) using fecal material from metformin-treated mice was found to upregulate the expression of GLP-1 and pattern-recognition receptors TLR1 and TLR4 for the improvement in hyperglycemia caused by a high-fat diet. Further, FMT downregulated the expression of the inflammatory cytokine IL-18. Within the genera Akkermansia, Bacteroides, and Butyricimonas, which were promoted by metformin therapy, Butyricimonas was found to be consistently abundant following FMT. Our findings suggest that modulation of gut microbiota is a key factor for the anti-inflammatory effects of metformin which is used for the treatment of hyperglycemia.

키워드

IL-18; Metformin; Gut microbiota; Fecal microbiota transplantation; Toll-like receptors; GLP-1
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