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Lactobacillus pentosus Modulates Immune Response by Inducing IL-10 Producing Tr1 Cells

Immune Network 2019년 19권 6호 p.39 ~ 39
 ( Kim Jung-Eun ) - SK Biopharmaceuticals

 ( Sharma Amit ) - Pohang University of Science and Technology Department of Life Sciences
 ( Sharma Garima ) - Pohang University of Science and Technology Department of Life Sciences
이소영 ( Lee So-Young ) - Korea Food Research Institute
신희순 ( Shin Hee-Soon ) - Korea Food Research Institute
 ( Rudra Dipayan ) - Pohang University of Science and Technology Department of Life Sciences
임신혁 ( Im Sin-Hyeog ) - Pohang University of Science and Technology Department of Life Sciences

Abstract


Several gut commensals have been shown to modulate host immune response. Recently, many food derived microbes have also been reported to affect the immune system. However, a mechanism to identify immunostimulatory and immunoregulatory microbes is needed. Here, we successfully established an in vitro screening system and identified an immunoregulatory bacterium, Lactobacillus pentosus KF340 (LP340), present in various fermented foods. LP340 induced a regulatory phenotype in mice Ag presenting cells which, in turn, induced IL-10 and IFN-γ producing Type 1 regulatory T cells (Tr1 cells) from naive CD4+ T cells. Naive CD4+ T cells co-cultured with LP340 treated dendritic cells highly expressed cytokine receptor IL-27R and were CD49b and lymphocyte-activation gene 3 double positive. Oral administration of LP340 in mice with atopic dermatitis reduced cellular infiltration in affected ear lobes and serum IgE levels, thus, ameliorating the disease symptoms. This suggests a systemic immunoregulatory effect of LP340. These findings demonstrate that LP340, a bacterium derived from food, prevents systemic inflammation through the induction of IL-10 producing Tr1 cells.

키워드

Tr1 cells; Lactobacillus pentosus; Interleukin-10; IL-10; Atopic dermatitis
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