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Prenatal Exposure to Lead and Chromium is Associated with IL-13 Levels in Umbilical Cord Blood and Severity of Atopic Dermatitis: COCOA Study

Immune Network 2019년 19권 6호 p.42 ~ 42
김지현 ( Kim Ji-Hyun ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Pediatrics

김선우 ( Kim Seon-Woo ) - Samsung Medical Center Statistics and Data Center
우숙영 ( Woo Sook-Young ) - Samsung Medical Center Statistics and Data Center
정진영 ( Chung Jin-Yong ) - Dong-A University Heavy Metal Exposure Environmental Health Center
 ( Hong Young-Seoub ) - Dong-A University Heavy Metal Exposure Environmental Health Center
오세용 ( Oh Se-Young ) - Kyung Hee University College of Human Ecology Department of Food and Nutrition
최석주 ( Choi Suk-Joo ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Obstetrics and Gynecology
오수영 ( Oh Soo-Young ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Obstetrics and Gynecology
김경원 ( Kim Kyung-Won ) - Yonsei University College of Medicine Department of Pediatrics
신윤호 ( Shin Youn-Ho ) - CHA University School of Medicine CHA Gangnam Medical Center Department of Pediatrics
원혜성 ( Won Hye-Sung ) - University of Ulsan College of Medicine Asan Medical Center Department of Obstetrics and Gynecology
이경주 ( Lee Kyung-Ju ) - Korea University College of Medicine Department of Obstetrics and Gynecology
김수현 ( Kim Soo-Hyun ) - CHA University School of Medicine CHA Gangnam Medical Center Department of Obstetrics and Gynecology
권자영 ( Kwon Ja-Young ) - Yonsei University College of Medicine Department of Obstetrics and Gynecology
 ( Lee Si-Hyeon ) - University of Ulsan College of Medicine Asan Medical Center Department of Pediatrics
홍수종 ( Hong Soo-Jong ) - University of Ulsan College of Medicine Asan Medical Center Department of Pediatrics
안강모 ( Ahn Kang-Mo ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Pediatrics

Abstract


There have been few studies investigating the association between atopic dermatitis (AD) and prenatal exposure to heavy metals. We aimed to evaluate whether prenatal exposure to heavy metals is associated with the development or severity of AD in a birth cohort study. A total of 331 subjects were followed from birth for a median duration of 60.0 months. The presence and severity of AD were evaluated at ages 6 and 12 months, and regularly once a year thereafter. The concentrations of lead, mercury, chromium, and cadmium in umbilical cord blood were measured by inductively coupled plasma mass spectrometry. Cord blood mononuclear cells (CBMCs) were isolated and stimulated for analysis of cytokine production using ELISA. Heavy metal levels in cord blood were not associated with the development of AD until 24 months of age. However, a positive correlation was observed between the duration of AD and lead levels in cord blood (p=0.002). AD severity was also positively associated with chromium concentrations in cord blood (p=0.037), while cord blood levels of lead, mercury, and cadmium were not significantly associated with AD severity (p=0.562, p=0.054, and p=0.055, respectively). Interleukin-13 production in CBMCs was positively related with lead and chromium levels in cord blood (p=0.021 and p=0.015, respectively). Prenatal exposure to lead and chromium is associated with the persistence and severity of AD, and the immune reaction toward a Th2 polarization.

키워드

Dermatitis, atopic; Cohort studies; Chromium; Fetal blood; Interleukin-13
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