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IL-17-Producing Cells in Tumor Immunity: Friends or Foes?

Immune Network 2020년 20권 1호 p.6 ~ 6
 ( Kuen Da-Sol ) - Seoul National University Research Institute of Pharmaceutical Sciences Laboratory of Immune Regulation

김병석 ( Kim Byung-Seok ) - Seoul National University Research Institute of Pharmaceutical Sciences Laboratory of Immune Regulation
 ( Chung Yeon-Seok ) - Seoul National University Research Institute of Pharmaceutical Sciences Laboratory of Immune Regulation

Abstract


IL-17 is produced by RAR-related orphan receptor gamma t (RORγt)-expressing cells including Th17 cells, subsets of γδT cells and innate lymphoid cells (ILCs). The biological significance of IL-17-producing cells is well-studied in contexts of inflammation, autoimmunity and host defense against infection. While most of available studies in tumor immunity mainly focused on the role of T-bet-expressing cells, including cytotoxic CD8+ T cells and NK cells, and their exhaustion status, the role of IL-17-producing cells remains poorly understood. While IL-17-producing T-cells were shown to be anti-tumorigenic in adoptive T-cell therapy settings, mice deficient in type 17 genes suggest a protumorigenic potential of IL-17-producing cells. This review discusses the features of IL-17-producing cells, of both lymphocytic and myeloid origins, as well as their suggested pro- and/or anti-tumorigenic functions in an organ-dependent context. Potential therapeutic approaches targeting these cells in the tumor microenvironment will also be discussed.

키워드

Tumor microenvironment; Th17 cells; Interleukin-17; T-lymphocytes
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