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한국 비흡연 성인의 간접흡연과 우울감의 연관성: 국민건강영양조사 2016년 자료 요코티닌 분석

Urine Cotinine for Assessing the Association between Secondhand Smoke Exposure and Depression in Adult Non-Smokers in Korea: Analysis of the Korea National Health and Nutrition Examination Survey 2016

대한임상건강증진학회지 2019년 19권 3호 p.138 ~ 144
김율희 ( Kim Yul-Hee ) - 경희의료원 가정의학과

김병성 ( Kim Byung-Sung ) - 경희의료원 가정의학과
원장원 ( Won Chang-Won ) - 경희의료원 가정의학과
 ( Kim Sun-Young ) - 경희의료원 가정의학과
장혜진 ( Jang Hye-Jin ) - 경희의료원 가정의학과


Background: Exposure to secondhand smoke (SHS) has been shown to cause health problems. Recent stud- ies demonstrated an association of SHS with depression and poor mental health. The urinary cotinine concen- tration (Ucot) is an objective indicator of exposure to SHS. In this study, we evaluated the association between depression and Ucot in adult non-smokers adults in Korea.

Methods: We analyzed the data of 3,417 adults, aged ≥ 19 years, who participated in the seventh Korea National Health and Nutrition Examination Survey (2016). The eligible subjects were non-smokers. Depression was evaluated using the Patient Health Questionnaire-9 (PHQ-9). The subjects were dichotomized into two groups: the high depressive symptom group (PHQ-9 ≥ 10 [n=185]) and the low depressive symptom group (PHQ-9 <10 [n=3,232]). The demographic, socioeconomic, and clinical characteristics of the subjects were re- trieved from the survey data. Ucot was dichotomized into high-Ucot (≥ 10 ng/mL) and low-Ucot (<10 ng/mL). The Ucot and other characteristics were compared between the two groups. To adjust for confounding varia- bles, we conducted a logistic regression analysis and determined the difference in Ucot between the two groups.

Results: After adjusting for confounders, the high depressive symptom group was found to be associated with high-Ucot (odds ratio, 1.824; 95% confidence interval, 1.020-3.262). Sex, education, socioeconomic status, marital status, occupational status, limitation of activity, and the presence of an underlying diseases (diabetes and dyslipidemia) had a significant effect on depression.

Conclusion: This concluded that depression was associated with high urine cotinine level in adult non- smokers.


Non-smokers; Tobacco; Cotinine; Depression; Korea National Health and Nutrition Survey
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