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헬리코박터 파일로리와 심혈관 질환

Helicobacter pylori and Cardiovascular Diseases

이주엽 ( Lee Ju-Yup ) - 계명대학교 의과대학 내과학교실

Abstract


Since its discovery, Helicobacter pylori (H. pylori) has played a central role in the pathogenesis of gastroduodenal diseases. Additionally, there have been many studies that demonstrated the role of H. pylori infection in extragastric diseases. Many research studies have confirmed an indirect association between the prevalence of H. pylori infection and the occurrence of cardiovascular diseases (CVDs); however, the results are still conflicting. Most studies found that the involvement of H. pylori in this process was related to the chronic inflammation. This inflammation may facilitate the development of CVD-related atherosclerotic pathologies such as endothelial damage and chronic activation of coagulation cascade, etc. Furthermore, H. pylori infection is known to be associated with other vascular diseases such as cerebrovascular diseases and cardiac arrhythmias, especially atrial fibrillation. This review summarized the literature on the association of cardiovascular manifestations and H. pylori infection and provided information about the pathogenesis of this association.

키워드

Atherosclerosis; Cardiovascular diseases; Heart diseases; Helicobacter pylori
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