medric medric
[닫기]
잠시만 기다려 주세요. 로딩중입니다.

Subdivision of Nasopharyngeal Carcinoma Patients with Bone-Only Metastasis at Diagnosis for Prediction of Survival and Treatment Guidance

Cancer Research and Treatment 2019년 51권 4호 p.1259 ~ 1268
 ( Sun Xue-Song ) - Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China

 ( Liang Yu-Jing ) - Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China
 ( Liu Sai-Lan ) - Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China
 ( Chen Qiu-Yan ) - Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China
 ( Guo Shan-Shan ) - Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China
 ( Wen Yue-Feng ) - Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China
 ( Liu Li-Ting ) - Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China
 ( Xie Hao-Jun ) - Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China
 ( Tang Qing-Nan ) - Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China
 ( Li Xiao-Yun ) - Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China
 ( Yan Jin-Jie ) - Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China
 ( Tang Lin-Quan ) - Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China
 ( Mai Hai-Qiang ) - Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China

Abstract


Purpose: The purpose of this study was to subdivide M1 stage nasopharyngeal carcinoma (NPC) patients with bone-only metastases for prognosis prediction while identifying the treatment effect of locoregional radiotherapy (LRRT) and metastasis radiotherapy (MRT) among patients with different risk.

Materials and Methods: From November 2006 to October 2016, a total of 226 patients with bone-only metastasic NPC were retrospectively enrolled. All patients developed distant lesions before receiving treatment. All potential prognostic factors were considered and the correlation of the M1 subdivisions with overall survival (OS) was determined by Cox regression hazards model. Kaplan?Meier curves were used to appraise survival condition and log-rank testing was used to compare the differences.

Results: The median follow-up time was 33.9 months (range, 3 to 126 months). According to multivariate Cox proportional hazard analysis, the number of metastatic lesions and Epstein-Barr virus (EBV) DNA status after palliative chemotherapy (PCT) were independent prognostic factors for OS. Thus, we subdivided patients into three risk groups according to these two factors. Systemic chemotherapy combined with LRRT may benefit patients in low- and intermediate-risk groups but not in the high-risk group. Further aggressive MRT based on systemic chemotherapy showed no survival benefit in any risk group.

Conclusion: The stratification of NPC patients with bone-only metastasis based on EBV DNA after PCT and the number of metastatic lesions provided promising prognostic value and could aid clinicians in person-specific treatment.

키워드

Nasopharyngeal carcinoma; Metastasis; Epstein-Barr virus; Radiotherapy; Survival
원문 및 링크아웃 정보
  
등재저널 정보
SCI(E)
MEDLINE
KCI
KoreaMed
KAMS