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Report of the Korean Association of Lung Cancer Registry (KALC-R), 2014

Cancer Research and Treatment 2019년 51권 4호 p.1400 ~ 1410
 ( Choi Chang-Min ) - University of Ulsan College of Medicine Asan Medical Center Department of Pulmonary and Critical Care Medicine

 ( Kim Ho-Cheol ) - University of Ulsan College of Medicine Asan Medical Center Department of Pulmonary and Critical Care Medicine
 ( Jung Chi-Young ) - Catholic University of Daegu School of Medicine Department of Internal Medicine
 ( Cho Deog-Gon ) - Catholic University College of Medicine St. Vincent’s Hospital Department of Thoracic and Cardiovascular Surgery
 ( Jeon Jae-Hyun ) - National Cancer Center Center for Lung Cancer
 ( Lee Jeong-Eun ) - Chungnam National University College of Medicine Department of Internal Medicine
 ( Ahn Jin-Seok ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Medicine
 ( Kim Seung-Joon ) - Catholic University College of Medicine Department of Internal Medicine
 ( Kim Yeong-Dae ) - Pusan National University Hospital Department of Thoracic and Cardiovascular Surgery
 ( Choi Yoo-Duk ) - Chonnam National University Medical School Department of Pathology
 ( Suh Yang-Gun ) - National Cancer Center Graduate School of Cancer Science and Policy Department of Cancer Control and Population Health
 ( Kim Jung-Eun ) - National Cancer Center Cancer Registration and Statistics Branch
 ( Lee Bo-Ram ) - National Cancer Center Cancer Registration and Statistics Branch
원영주 ( Won Young-Joo ) - National Cancer Center Cancer Registration and Statistics Branch
 ( Kim Young-Chul ) - Chonnam National University Hwasun Hospital Department of Internal Medicine

Abstract


Purpose: The aim of this study was to investigate epidemiology, clinical characteristics and sex differences of patients with lung cancer using nationwide registry in Korea.

Materials and Methods: The Korean Association for Lung Cancer developed a registry in cooperation with the Korean Central Cancer Registry, and surveyed about 10% of lung cancer cases. For this first survey of cases diagnosed in 2014, cases were selected through a systematic sampling method.

Results: Total 2,621 lung cancer patients were surveyed, and the median patient age was 70 years. During the study period, adenocarcinoma was the most frequent histologic type, the proportion of female patients was 28.4%, and women had a better prognosis (median survival, not reached vs. 13 months; p<0.001) than did men for non-small cell lung cancer. The proportion of never-smokers was 36.4%, and never-smoking was more prevalent in women than in men (87.5 vs. 16.0%, p<0.001). Epidermal growth factor receptor (EGFR) mutations were found in 36.8% of stage IV adenocarcinoma patients, and higher in female compared to male patients (51.2 vs. 26.6%, p<0.001). In addition, patients with EGFR mutation showed better survival (median survival, 18 vs. 8 months; p<0.001) than patients without EGFR mutation in these patients.

Conclusion: This is the first survey to gather unbiased nationwide lung cancer statistics in Korea. More than one-third of lung cancer patients had no smoking history. Female had a high proportion of non-smoker, more adenocarcinoma with EGFR mutation and generally better prognosis than male.

키워드

Lung neoplasms; Epidemiology; Korea; Never-smokers; Epidermal growth factor receptor
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