medric medric
[닫기]
잠시만 기다려 주세요. 로딩중입니다.

Prognostic Value of Baseline and Interim Total Metabolic Tumor Volume and Total Lesion Glycolysis Measured on 18F-FDG PET-CT in Patients with Follicular Lymphoma

Cancer Research and Treatment 2019년 51권 4호 p.1479 ~ 1487
 ( Liang Jin-Hua ) - Nanjing Medical University First Affiliated Hospital Department of Hematology

 ( Zhang Yun-Ping ) - Nanjing Medical University First Affiliated Hospital Department of Hematology
 ( Xia Jun ) - Nanjing Medical University First Affiliated Hospital Department of Hematology
 ( Ding Chong-Yang ) - Nanjing Medical University First Affiliated Hospital Department of Nuclear Medicine
 ( Wu Wei ) - Nanjing Medical University First Affiliated Hospital Department of Hematology
 ( Wang Li ) - Nanjing Medical University First Affiliated Hospital Department of Hematology
 ( Cao Lei ) - Nanjing Medical University First Affiliated Hospital Department of Hematology
 ( Zhu Hua-Yuan ) - Nanjing Medical University First Affiliated Hospital Department of Hematology
 ( Fan Lei ) - Nanjing Medical University First Affiliated Hospital Department of Hematology
 ( Li Tian-Nv ) - Nanjing Medical University First Affiliated Hospital Department of Nuclear Medicine
 ( Li Jian-Yong ) - Nanjing Medical University First Affiliated Hospital Department of Hematology
 ( Xu Wei ) - Nanjing Medical University First Affiliated Hospital Department of Hematology

Abstract


Purpose: The purpose of this study was to investigate the prognostic significance of total metabolic tumor volume (TMTV) and total lesion glycolysis (TLG) in patients with follicular lymphoma (FL) at baseline and mid-treatment with 18F-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) scans.

Methods: The study analyzed data from 48 patients with FL who were treated in Jiangsu Province Hospital and reviewed their baseline PET-CT scans. TMTV and TLG were computed by using the absolute value of 2.0, 2.5, and 3.0 thresholding method, respectively.

Results: Median age was 53 years, 75.0% of patients had stage III to IV disease, 43.8% had a Follicular Lymphoma International Prognostic Index 1 (FLIPI1) score of 3 to 5 and 20.8% had a FLIPI2 score of 3 to 5. Receiver operating characteristic (ROC) curve analysis showed the optimal cut-off values for TMTV3.0 and TLG3.0 were 476.4 (sensitivity, 85.7%; specificity, 78.0%; area under the curve [AUC], 0.760; p=0.003) and 2,676.9 (sensitivity, 71.4%; specificity, 78.0%; AUC, 0.760; p=0.003). On multivariable analysis, TMTV3.0 and TLG3.0 were independent predictors of both progression-free survival (PFS) (hazard ratio [HR], 5.406; 95% confidence interval [CI], 1.326 to 22.040; p=0.019 and HR, 6.502; 95% CI, 1.079 to 39.182; p=0.042) and overall survival (OS) (HR, 4.111; 95% CI, 1.125 to 15.027; p=0.033 and HR, 5.885; 95% CI, 1.014 to 34.148; p=0.049). ROC curve analysis showed the optimal cut-off values for ΔTMTV3.0 and ΔTLG3.0 were 66.3% (sensitivity, 85.7%; specificity, 63.4%; AUC, 0.774; p < 0.001) and 64.5% (sensitivity, 85.7%; specificity, 65.9%; AUC, 0.777; p < 0.001).

Conclusion: Baseline TMTV and TLG are strong predictors of PFS and OS in FL. Furthermore, interim TMTV (ΔTMTV > 66.3%) and TLG (ΔTLG > 64.5%) reduction are valuable tools for early treatment response assessment in FL patients.

키워드

Follicular lymphoma; Prognosis; Total metabolic tumor volume; Total lesion glycolysis; The maximum of standard uptake value
원문 및 링크아웃 정보
  
등재저널 정보
SCI(E)
MEDLINE
KCI
KoreaMed
KAMS