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Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis

Cancer Research and Treatment 2019년 51권 4호 p.1653 ~ 1665
 ( Li Nan ) - Yanbian University Medical College Department of Pathology

 ( Piao Junjie ) - Yanbian University Medical College Department of Pathology
 ( Wang Xinyue ) - Yanbian University Medical College Department of Pathology
 ( Kim Ki-Yeol ) - Yonsei University College of Dentistry Brain Korea 21 Project
 ( Bae Jung-Yoon ) - Yonsei University College of Dentistry Oral Cancer Research Institute
 ( Ren Xiangshan ) - Yanbian University Medical College Department of Pathology
 ( Lin Zhenhua ) - Yanbian University Medical College Department of Pathology

Abstract


Purpose: This study was aimed to investigate the role of poly(A)-binding protein-interacting protein 1 (Paip1) in cervical carcinogenesis.

Materials and Methods: The expression of Paip1 in normal cervical epithelial tissues and cervical cancer (CC) tissues were detected by immunohistochemistry. In vivo and in vitro assays were performed to validate effect of Paip1 on CC progression.

Results: Paip1 was found to be up-regulated in CC, which was linked with shorter survival. Knockdown of Paip1 inhibited cell growth, induced apoptosis and cell cycle arrest in CC cells, whereas its overexpression reversed these effects. The in vivo tumor model confirmed the pro-tumor role of Paip1 in CC growth.

Conclusion: Altogether, the investigation demonstrated the clinical significance of Paip1 expression, which prompted that the up-regulated of Paip1 can presumably be a potential prognostic and progression marker for CC.

키워드

Uterine cervical neoplasms; Proliferation; Cell cycle; Apoptosis
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