잠시만 기다려 주세요. 로딩중입니다.

The prevalence of sarcopenia and its effect on prognosis in patients with Crohn’s disease

Intestinal Research 2020년 18권 1호 p.79 ~ 84
 ( Lee Chan-Hyung ) - Seoul National University College of Medicine Department of Internal Medicine

윤혁 ( Yoon Hyuk ) - Seoul National University Bundang Hospital Department of Internal Medicine
오동준 ( Oh Dong-Jun ) - Seoul National University Bundang Hospital Department of Internal Medicine
 ( Lee Jae-Min ) - Seoul National University Bundang Hospital Department of Internal Medicine
최윤진 ( Choi Yoon-Jin ) - Seoul National University Bundang Hospital Department of Internal Medicine
신철민 ( Shin Cheol-Min ) - Seoul National University Bundang Hospital Department of Internal Medicine
박영수 ( Park Young-Soo ) - Seoul National University Bundang Hospital Department of Internal Medicine
김나영 ( Kim Na-Young ) - Seoul National University College of Medicine Department of Internal Medicine
이동호 ( Lee Dong-Ho ) - Seoul National University College of Medicine Department of Internal Medicine
김주성 ( Kim Joo-Sung ) - Seoul National University College of Medicine Department of Internal Medicine

Abstract


Background/Aims: Crohn’s disease is associated with altered body composition, such as low muscle mass, which can affect clinical outcomes. However, there are few studies regarding the effect of sarcopenia on prognosis of Crohn’s disease. In this study, we evaluated the body composition at the initial diagnosis of Crohn’s disease and analyzed the clinical meaning of sarcopenia.

Methods: We conducted a retrospective review of medical records of patients who were diagnosed as Crohn’s disease and underwent computed tomography within 3 months after diagnosis. Sarcopenia was defined as an L3 skeletal muscle index (SMI) of < 49 cm2/m2 for men and < 31 cm2/m2 for women. Outcomes such as need for hospitalization, surgery, use of steroids, immunomodulators and biologics were analyzed.

Results: A total of 79 patients (male, 73.4%; mean age, 29.9 years) were included and 40 patients (51%) were diagnosed as sarcopenia. C-reactive protein (CRP) level was correlated with sarcopenia (P= 0.044). Erythrocyte sedimentation rate (ESR) showed a tendency to decrease inversely with SMI (r = ?0.320, P= 0.008) and hemoglobin and albumin tended to increase in proportion to SMI (hemoglobin: r = 0.271, P= 0.016 and albumin: r = 0.350, P= 0.002). However, there was no statistically significance in time-to-first-event analysis in aspects of sarcopenia.

Conclusions: Approximately 50% of patients with newly diagnosed as Crohn’s disease had sarcopenia. CRP levels were higher in the sarcopenia group and SMI correlated with ESR, hemoglobin, and albumin. However, none of prognostic values were demonstrated.

키워드

Crohn disease; Prevalence; Sarcopenia; Prognosis
원문 및 링크아웃 정보
  
등재저널 정보