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Proinflammatory cytokines in irritable bowel syndrome: a comparison with inflammatory bowel disease

Intestinal Research 2020년 18권 1호 p.115 ~ 120
 ( Mitselou Antigony ) - University of Ioannina Medical School Department of Forensic Pathology

 ( Grammeniatis Vasileios ) - General Hospital of Ioannina Department of Paediatrics
 ( Varouktsi Anna ) - Ippokratio Hospital Department of Internal Medicine
 ( Papadatos Stamatis S. ) - National and Kapodistrian University of Athens Medical School Sotiria General Hospital Department of Internal Medicine
 ( Katsanos Konstantinos H. ) - University of Ioannina School of Health Sciences Department of Internal Medicine
 ( Galani Vasiliki ) - University of Ioannina Medical School Department of Anatomy, Histology and Embryology

Abstract


Background/Aims: Irritable bowel syndrome (IBS) is a common disease often considered as a functional intestinal disorder. Inflammation in IBS is a quite intriguing theory. The aim of this study was to investigate tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6 expression in inflammatory bowel disease (IBD) patients, IBS patients and normal controls.

Methods: IBS and IBD patients along with normal controls were recruited in the study. In all groups, 2 pinch biopsies were taken at each of 3 anatomical sites (terminal ileum, cecum, and rectum). IBS patients were also subcategorized according to the syndrome clinical manifestations. Two monoclonal antibodies (mAb), TNF-α mAb and IL-6 mAb, and one polyclonal antibody IL-1β mAb were applied for immunohistochemical analysis.

Results: In IBD patients intensity of TNF-α and IL-1β were lower than in IBS patients or controls, while IL-6 was significantly increased comparing to the aforementioned groups. In IBS patients TNF-α was increased comparing to IBD patients or controls, while IL-6 and IL-1β were similar to controls. In IBS subgroups, TNF-α was lower in diarrhea predominant IBS patients and higher constipation predominant IBS patients. Differences among IBS subgroups regarding IL-6 and IL-1β were nonsignificant.

Conclusions: IL-6 seems to be the most important proinflammatory cytokine in IBD patients, while TNF-α could play a more significant role in IBS pathogenesis.

키워드

Proinflammatory cytokines; Irritable bowel syndrome; Inflammatory bowel disease
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