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당뇨력과 전립선암 발생 위험도: 동아시아 남성 코호트 연구에 대한 메타역학 연구

History of Diabetes Mellitus and Risk of Prostate Cancer: A Meta-Epidemiological Study of Population-Based Cohort Studies in East Asian Men

대한비뇨기종양학회지 2019년 17권 3호 p.119 ~ 124
배종면 ( Bae Jong-Myon ) - 제주대학교 의과대학 예방의학교실

Abstract


Purpose: Seven quantitative systematic reviews previously published showed that the direction of risk of prostate cancer associated with history of diabetes mellitus was in the opposite. The aim of this meta-epidemiological meta-analysis (MEMA) was to evaluate the effect size and direction of the prostate cancer risk associated with history of diabetes mellitus in Far East Asian men from population-based cohort studies.

Materials and Methods: The primary subjects of MEMA were the 7 Asian cohort studies selected by related systematic reviews. Additional articles were searched from the primary subjects using citation discovery tools. The study having the longest follow-up period was selected from studies having the same cohorts. Random effect model was applied to estimate a summary relative risk (sRR) and its 95% confidence intervals (CIs). Egger test was used to evaluate a publication bias.

Results: Three cohort studies were selected finally. These participants were population of Korea, Taiwan, and Japan, respectively, and total participants were 1,475,465. The direction of risk among 3 studies of Far East Asian men was in the opposite direction. The sRR (and its 95% CI) (l-squared value) was 1.07 (0.71?1.62) (86.1%).

Conclusions: This MEMA found that the direction as well as effect size of risk of prostate cancer associated with history of diabetes mellitus in Far East Asian men were inconsistent and heterogenous. To overcome them, it would be necessary to elongate cohort follow-up period, to adjust for potential confounders including socioeconomic status, and to consider conducting rates of prostate specific antigen test by national screening guideline.

키워드

Diabetes mellitus; Prostate neoplasm; Meta-analysis; Cohort studies
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