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Prostate Carcinosarcoma Developing After Combined Pelvic External Beam Radiation Therapy and Androgen Deprivation Therapy

대한비뇨기종양학회지 2019년 17권 3호 p.195 ~ 198
김영주 ( Kim Young-Joo ) - Jeju National University School of Medicine Jeju National University Hospital Department of Urology

Abstract


Carcinosarcoma of the prostate is a very rare disease, which consists of carcinomatous and sarcomatous components. The prognosis of patients with prostatic carcinosarcoma is poor. An 80-year-old man who had been suffering from urinary retention and constipation with rectal pain visited a hospital. A patient with a history of combined pelvic external beam radiation therapy (EBRT) and androgen deprivation therapy (ADT) for prostate adenocarcinoma 7 years ago was diagnosed with secondary malignancy such as prostate carcinosarcoma by prostate biopsy. This is also a rare case occurring after combined EBRT and ADT for adenocarcinoma in a short interval. Then, he underwent chemotherapy for one cycle. Chemotherapy was stopped because of rapid clinical aggravation, and the patient died 5 months later. It is important to keep in mind the possibility of carcinosarcoma in the case that prostate-specific antigen maintains stable level but extent of tumor is gradually increased after EBRT or ADT.

키워드

Prostate; Carcinosarcoma; Prognosis
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