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Effect of Chrysanthemum indicum Linne extract on melanogenesis through regulation of TGF-β/JNK signaling pathway

Food Science and Biotechnology 2019년 28권 5호 p.1577 ~ 1582
 ( Hwang Yong-Il ) - Kyunam University School of Bioconvergence


Although several physiological effects of Chrysanthemum indicum Linne (CL) have been researched, the specific effect and molecular mechanism of CL as a functional food material for skin health remain still unknown. Here, it was observed that the α-MSH and IBMX-initiated B16F10 melanogenesis was suppressed by the CL water extract (CLE) treatment. The CLE treatment also increased the mRNA expression levels of pro-collagen1α2, collagen1α2, and fibronectin via exerting the TGF-β/JNK signaling pathway. Together, the beneficial role of CLE in skin health was demonstrated through the downregulation of melanogenesis and enhancement of skin fibril-related genes. It was also revealed that the function of CLE is mediated with the activation of the TGF-β/JNK signaling pathway. These results may provide evidences for the development of functional foods using CLE for maintaining healthy skin.


Chrysanthemum indicum Linne; Skin; TGF-β; Melanin; Skin fibril
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