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Differences in 25-hydroxy vitamin D and vitamin D-binding protein concentrations according to the severity of endometriosis

Clinical and Experimental Reproductive Medicine 2019년 46권 3호 p.125 ~ 131
 ( Baek Jong-Chul ) - Gyeongsang National University Changwon Hospital Department of Obstetrics and Gynecology

 ( Jo Jae-Yoon ) - Gyeongsang National University Hospital Department of Obstetrics and Gynecology
 ( Lee Seon-Mi ) - Gyeongsang National University Hospital Department of Obstetrics and Gynecology
 ( Cho In-Ae ) - Gyeongsang National University Hospital Department of Obstetrics and Gynecology
 ( Shin Jeong-Kyu ) - Gyeongsang National University Hospital Department of Obstetrics and Gynecology
 ( Lee Soon-Ae ) - Gyeongsang National University Hospital Department of Obstetrics and Gynecology
 ( Lee Jong-Hak ) - Gyeongsang National University Hospital Department of Obstetrics and Gynecology
 ( Cho Min-Chul ) - Gyeongsang National University Institute of Health Sciences
 ( Choi Won-Jun ) - Gyeongsang National University Hospital Department of Obstetrics and Gynecology

Abstract


Objective: To investigate serum 25-hydroxyl vitamin D (25(OH)D) and vitamin D-binding protein (VDBP) concentrations in women with endometriosis according to the severity of disease.

Methods: Women with mild endometriosis (n = 9) and advanced endometriosis (n = 7), as well as healthy controls (n = 16), were enrolled in this observational study. Serum total 25(OH)D concentrations were analyzed using the Elecsys vitamin D total kit with the Cobas e602 module. Concentrations of bioavailable and free 25(OH)D were calculated. Concentrations of VDBP were measured using the Human Vitamin D BP Quantikine ELISA kit. Variables were tested for normality and homoscedasticity using the Shapiro-Wilk test and Leven F test, respectively. Correlation analysis was used to identify the variables related to total 25(OH)D and VDBP levels. To assess the effects of total 25(OH)D and VDBP levels in the three groups, multivariate generalized additive modeling (GAM) was performed.

Results: Gravidity and parity were significantly different across the three groups. Erythrocyte sedimentation rate (ESR) and CA-125 levels increased as a function of endometriosis severity, respectively (p= 0.051, p= 0.004). The correlation analysis showed that total 25(OH)D levels were positively correlated with gravidity (r = 0.59, p< 0.001) and parity (r = 0.51, p< 0.003). Multivariate GAM showed no significant relationship of total 25(OH)D levels with EMT severity after adjusting for gravidity and ESR. However, the coefficient of total 25(OH)D levels with gravidity was significant (1.87; 95% confidence interval, 0.12?3.63; p= 0.040).

Conclusion: These results indicate that vitamin D and VDBP levels were not associated with the severity of endometriosis.

키워드

Endometriosis; Vitamin D; Vitamin D-binding protein
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