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Neuroprotective effect of green tea extractives against oxidative stress by enhancing the survival and proliferation of PC12 cells

Molecular & Cellular Toxicology 2019년 15권 4호 p.391 ~ 397
 ( Cai Zhenlu ) - Xi’an Jiaotong University Health Science Center School of Basic Medical Sciences Department of Neurobiology

 ( Hu Xiaoxuan ) - Xi’an Jiaotong University Health Science Center School of Basic Medical Sciences Department of Neurobiology
 ( Tan Ruolan ) - Xi’an Jiaotong University Health Science Center School of Basic Medical Sciences Department of Neurobiology
 ( Feng Yunran ) - Tianjin University School of Pharmaceutical Science and Technology
 ( Sun Meiqi ) - Xi’an Jiaotong University Health Science Center School of Basic Medical Sciences Department of Neurobiology
 ( Ma Ning ) - Xi’an Jiaotong University Health Science Center School of Basic Medical Sciences Department of Neurobiology
 ( Li Xingxing ) - Xi’an Jiaotong University Health Science Center School of Basic Medical Sciences Department of Neurobiology
 ( Huang Li ) - Xi’an Jiaotong University Health Science Center School of Basic Medical Sciences Department of Neurobiology
 ( An Jing ) - Xi’an Jiaotong University Health Science Center School of Basic Medical Sciences Department of Neurobiology
 ( Ge Qian ) - Xi’an Jiaotong University Health Science Center School of Basic Medical Sciences Department of Neurobiology
 ( Lu Haixia ) - Xi’an Jiaotong University Health Science Center School of Basic Medical Sciences Department of Neurobiology

Abstract


Backgrounds: Previous studies were mainly focused on the effect of catechins and caffeine, the main pharmacological ingredients of green tea. However, the ordinary way of taking green tea is by drinking the tea water. Hence the benefits of water extractives of green tea were investigated in the current study.

Methods: H2O2 was applied to induce the oxidative stress on PC12 cells. The neuroprotective effects of green tea against oxidative stress were determined by observing the biological behaviors of PC12 cells.

Results: With the pre-treatment of light green tea, the survival and proliferation of oxidative stressed PC12 cells were significantly enhanced. H2O2 induced PC12 cell apoptosis was completely reversed. Consistently, the expression of JNK was up-regulated while the caspase-3 was down-regulated.

Conclusion: These results suggested that drinking green tea, particularly the light green tea, performed neuroprotective effects against oxidative stress.

키워드

Green tea; Water extractives; Neuroprotective effects; Oxidative stress; PC12 cells
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