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The protective effects of echinochrome A structural analogs against oxidative stress and doxorubicin in AC16 cardiomyocytes

Molecular & Cellular Toxicology 2019년 15권 4호 p.407 ~ 414
 ( Yoon Chang-Shin ) - Inje University College of Medicine Department of Physiology

 ( Kim Hyoung-Kyu ) - Inje University College of Medicine Department of Physiology
 ( Mishchenko Natalia P. ) - Russian Academy of Sciences Far Eastern Branch G. B. Elyakov Pacific Institute of Bioorganic Chemistry
 ( Vasileva Elena A. ) - Russian Academy of Sciences Far Eastern Branch G. B. Elyakov Pacific Institute of Bioorganic Chemistry
 ( Fedoreyev Sergey A. ) - Russian Academy of Sciences Far Eastern Branch G. B. Elyakov Pacific Institute of Bioorganic Chemistry
 ( Shestak Olga P. ) - Russian Academy of Sciences Far Eastern Branch G. B. Elyakov Pacific Institute of Bioorganic Chemistry
 ( Balaneva Nadezhda N. ) - Russian Academy of Sciences Far Eastern Branch G. B. Elyakov Pacific Institute of Bioorganic Chemistry
 ( Novikov Vyacheslav L. ) - Russian Academy of Sciences Far Eastern Branch G. B. Elyakov Pacific Institute of Bioorganic Chemistry
 ( Stonik Valentin A. ) - Russian Academy of Sciences Far Eastern Branch G. B. Elyakov Pacific Institute of Bioorganic Chemistry
 ( Han Jin ) - Inje University College of Medicine Department of Physiology

Abstract


Backgrounds: Echinochrome A (6-ethyl-2,3,5,7,8-pen-tahydroxy-1,4-naphthoquinone) is a common naphthoquinone pigment found in the shells, spines, and coelomic fluid of sea urchins. We previously reported that echinochrome A has a cardioprotective function as an antioxidant against reactive oxygen species (ROS) induced by tert-Butyl hydroperoxide and doxorubicin.

Methods: In the current study, we evaluated the antioxidant activity, ATP production, and oxygen consumption rate (OCR) of seven echinochrome structural analogs (spinochromes) in AC16 human cardiomyocyte cells. The compounds included in the study had various substituents including hydroxyl (Sp B and Sp E), amino (Echm A), methoxyl (TriMeEch A), pentyl (No. 284), and hydroxypentyl (No. 285). We also investigated the effects of one dimeric spinochrome (Binaphthoquinone).

Results: Spinochromes exhibited enhanced antioxidant activity and ATP production. Interestingly, the hydroxylated compounds significantly enhanced the OCR and had a cardiomyocyte protective effect in the presence of doxorubicin.

Conclusion: Our findings indicate that echinochrome A structural analogs may have therapeutic potential for cardio-protection.

키워드

Echinochrome A; Spinochromes; Structural analogs; Cardioprotective effect; Doxorubicin
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