medric medric
[닫기]
잠시만 기다려 주세요. 로딩중입니다.

Genetic aspects of type 1 diabetes

Annals of Pediatric Endocrinology & Metabolism 2019년 24권 3호 p.143 ~ 148
 ( Lee Hae-Sang ) - Ajou University School of Medicine Ajou University Hospital Department of Pediatrics

 ( Hwang Jin-Soon ) - Ajou University School of Medicine Ajou University Hospital Department of Pediatrics

Abstract


Type 1 diabetes mellitus (T1DM) is characterized by autoimmune destruction of pancreatic beta-cells in genetically predisposed individuals, eventually resulting in severe insulin deficiency. It is the most common form of diabetes in children and adolescents. Genetic susceptibility plays a crucial role in development of T1DM. The human leukocyte antigen complex plays a key role in the pathogenesis of T1DM. Furthermore, genome-wide association studies and linkage analysis have recently made a significant contribution to current knowledge relative to the impact of genetics on T1DM development and progression. This review focuses on current knowledge of genetics as a pathogenesis for T1DM. It also discusses mechanisms by which genes influence the risk of developing T1DM as well as the clinical and research applications of genetic risk scores in T1DM.

키워드

Type 1 diabetes; GWAS; Human leukocyte antigen; Genetic risk score
원문 및 링크아웃 정보
 
등재저널 정보