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Immunohistochemical Expression of Epithelial-Mesenchymal Transition Markers in Early Gastric Cancer: Cancer Tissue versus Noncancer Tissue

Clinical Endoscopy 2019년 52권 5호 p.464 ~ 471
 ( Jung Hee-Jae ) - Soonchunhyang University College of Medicine Department of Internal Medicine

홍수진 ( Hong Su-Jin ) - Soonchunhyang University College of Medicine Department of Internal Medicine
 ( Kim Shin-Hee ) - Soonchunhyang University College of Medicine Department of Internal Medicine


Background/Aims: Epithelial-mesenchymal transition (EMT) is a developmental process, wherein the epithelial cells show reduced intercellular adhesions and acquire migratory fibroblastic properties. EMT is associated with downregulation in epithelial marker expression, abnormal translocation of E-cadherin, and upregulation in mesenchymal marker expression. Here, we investigated the immunohistochemical (IHC) expression of EMT markers in early gastric cancer (EGC) between cancer and noncancer tissues.

Methods: Tissue samples were prospectively obtained from 19 patients with EGC that underwent endoscopic submucosal dissection (ESD). We compared the expression level of transforming growth factor (TGF)-β, vascular endothelial growth factor (VEGF), E-cadherin, α-smooth muscle actin (α-SMA), and vimentin between cancer and noncancer tissues using IHC. Among the 19 patients, 15 patients had follow-up biopsy at 3 months after ESD for EGC.

Results: Cancer tissues presented higher values of EMT mesenchymal markers (α-SMA/vimentin/TGF-β/VEGF) than the noncancerous tissues (p<0.05) that were significantly low after ESD (p<0.05). No significant correlation was reported for tumor location and initial Helicobacter pylori infection.

Conclusions: The mesenchymal expression of EMT markers was higher in the cancerous tissues than in the noncancer tissues.


Epithelial-mesenchymal transition; Immunohistochemistry; Early gastric cancer; Endoscopic submucosal dissection
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