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Dosimetric Effects of Intrafractional Organ Motion in Field-in-Field Technique for Whole-Breast Irradiation

Progress in Medical Physics 2019년 30권 3호 p.65 ~ 73
 ( Hong Chae-Seon ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Radiation Oncology

 ( Ju Sang-Gyu ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Radiation Oncology
최두호 ( Choi Doo-Ho ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Radiation Oncology
 ( Han Young-Yih ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Radiation Oncology
 ( Huh Seung-Jae ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Radiation Oncology
 ( Park Won ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Radiation Oncology
 ( Ahn Yong-Chan ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Radiation Oncology
 ( Kim Jin-Sung ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Radiation Oncology
 ( Lim Do-Hoon ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Radiation Oncology

Abstract


Purpose: We evaluated the motion-induced dosimetric effects on the field-in-field (FIF) technique for whole-breast irradiation (WBI) using actual patient organ motion data obtained from cine electronic portal imaging device (cine EPID) images during treatment.

Materials and Methods: Ten breast cancer patients who received WBI after breast-conserving surgery were selected. The static FIF (SFIF) plan involved the application of two parallel opposing tangential and boost FIFs. To obtain the amplitude of the internal organ motion during treatment, cine EPID images were acquired five times for each patient. The outside contour of the breast (OCB) and chest wall (CW) contour were tracked using in-house motion analysis software. Intrafractional organ motion was analyzed. The dynamic FIF (DFIF) reflecting intrafractional organ motion incorporated into the SFIF plan was calculated and compared with the SFIF in terms of the dose homogeneity index (DHI90/10) for the target and V20 for the ipsilateral lung.

Results: The average motion amplitudes along the X and Y directions were 1.84±1.09 mm and 0.69±0.50 mm for OCB and 1.88±1.07 mm and 1.66±1.49 mm for CW, respectively. The maximum motion amplitudes along the X and Y directions were 5.53 and 2.08 mm for OCB and 5.22 and 6.79 mm for CW, respectively. Significant differences in DHI90/10 values were observed between SFIF and DFIF (0.94 vs 0.95, P<0.05) in statistical analysis. The average V20 for the lung in the DFIF was slightly higher than that of the SFIF in statistical analysis (19.21 vs 19.00, P<0.05).

Conclusion: Our findings indicate that the FIF technique can form a safe and effective treatment method for WBI. Regular monitoring using cine EPID images can be effective in reducing motion-induced dosimetric errors.

키워드

Dose variation; Field-in-field technique; Organ motion; Whole-breast irradiation
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