medric medric
[닫기]
잠시만 기다려 주세요. 로딩중입니다.

The Role of Two Human Milk Oligosaccharides, 2′-Fucosyllactose and Lacto-N-Neotetraose, in Infant Nutrition

 ( Hegar Badriul ) - University of Indonesia Faculty of Medicine Cipto Mangunkusumo Hospital

 ( Wibowo Yulianti ) - Nestle Nutrition Institute
 ( Basrowi Ray Wagiu ) - Nestle Nutrition Institute
 ( Ranuh Reza Gunadi ) - University Airlangga Faculty of Medicine Soetomo Hospital
 ( Sudarmo Subianto Marto ) - University Airlangga Faculty of Medicine Soetomo Hospital
 ( Munasir Zakiudin ) - University of Indonesia Faculty of Medicine Cipto Mangunkusumo Hospital
 ( Atthiyah Alpha Fardah ) - University Airlangga Faculty of Medicine Soetomo Hospital
 ( Widodo Ariani Dewi ) - Harapan Kita Hospital
 ( Supriatmo ) - Adam Malik Hospital
 ( Kadim Muzal ) - University of Indonesia Faculty of Medicine Cipto Mangunkusumo Hospital
 ( Suryawan Ahmad ) - University Airlangga Faculty of Medicine Soetomo Hospital
 ( Diana Ninung Rose ) - Kariadi Hospital
 ( Manoppo Christy ) - Kandou Hospital
 ( Vandenplas Yvan ) - Vrije Universiteit Brussel Universitair Ziekenhuis Brussel Kidz Health Castle

Abstract


Human breast milk contains numerous biomolecules. Human milk oligosaccharides (HMOs) are the third most abundant component of breast milk, after lactose and lipids. Amongst the synthetized HMOs, 2′-fucosyllactose (2′-FL) and lacto-N-neotetraose (LNnT) are widely studied and are considered safe for infant nutrition. Several studies have reported the health benefits of HMOs, which include modulation of the intestinal microbiota, anti-adhesive effect against pathogens, modulation of the intestinal epithelial cell response, and development of the immune system. The amount and diversity of HMOs are determined by the genetic background of the mothers (HMO secretors or non-secretors). The non-secretor mothers secrete lower HMOs than secretor mothers. The breastfed infants of secretor mothers gain more health benefit than those of non-secretor mothers. In conclusion, supplementation of infant formula with 2′-FL and LNnT is a promising innovation for infant nutrition.

키워드

Human milk; Oligosaccharide; 2′-fucosyllactose; Lacto-N-neotetraose; Infant; Breast feeding
원문 및 링크아웃 정보
 
등재저널 정보
KCI
KoreaMed