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광업 이직근로자에서 잠복결핵감염 위험요인 분석

Risk Factors for Associated with Latent Tuberculosis Infection among Former Mine Workers

한국산업보건학회지 2019년 29권 3호 p.289 ~ 297
황주환 ( Hwang Joo-Hwan ) - 근로복지공단 직업환경연구원

신재훈 ( Shin Jae-Hoon ) - 근로복지공단 직업환경연구원
백진이 ( Baek Jin-Ee ) - 근로복지공단 직업환경연구원
최병순 ( Choi Byung-Soon ) - 근로복지공단 직업환경연구원


Objectives: To identify the positive rate of and the risk factors associated with latent tuberculosis infection(LTBI) in mine workers, the objectives of the present study evaluated those among former mine workers.

Methods: Between January 2015 and May 2017, former male mine workers who had been subjects for epidemiology research for work-related chronic obstructive pulmonary disease(COPD) and had received QuantiFERON-TB® Gold In-Tube(QFT-GIT) from the Institute of Occupation and Environment(IOE) under Korea Workers’ Compensation and Welfare Service(KCOMWEL) were selected as the study subjects. To identify significant variables for increased risk of LTBI, logistic regression analysis was performed.

Results: A total of 736 male former mine workers were selected as study subjects. The positive rate of LTBI among subjects was 69.2%(509/736). The current smoking[odds ratio(OR), 2.3; 95% confidence interval(CI), 1.1-4.9], COPD(OR, 1.4; 95% CI, 0.9-2.3), department loading(OR, 1.8; 95% CI, 0.9-3.4) and mining(OR, 1.5; 95% CI, 0.9-2.5), and working duration of over 20(OR, 1.6; 95% CI, 0.9-3.1) and over 30 years(OR, 2.2; 95% CI, 0.9-4.9) were associated with increased risk of LTBI. The interferon-gamma(IFN-γ) level after stimulation with M y c o b a c t e ri u m t u b e r c u l o s i s (MTB)-specific antigens showed a significantly negative correlation with age( r =-0.126).

Conclusions: The present study determined that the high positive rate of LTBI among mine workers was associated with not only the host factors but also the occupational exposure to mine dust.


Chronic obstructive pulmonary disease; latent tuberculosis infection; mine worker; QuantiFERON-TB® Gold In-Tube
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