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광물성 분진 노출 이직노동자에서 만성폐쇄성폐질환과 호기응축액 중의 malondialdehyde 및 혈청 염증지표 간의 관련성

The Relationship between Malondialdehyde in Exhaled Breath Condensate and Inflammatory Markers in Serum and COPD in Retired Workers Exposed to Mineral Dust

한국산업보건학회지 2019년 29권 3호 p.404 ~ 413
이종성 ( Lee Jong-Seong ) - 근로복지공단 직업환경연구원

신재훈 ( Shin Jae-Hoon ) - 근로복지공단 직업환경연구원
백진이 ( Baek Jin-Ee ) - 근로복지공단 직업환경연구원
최병순 ( Choi Byung-Soon ) - 근로복지공단 직업환경연구원

Abstract


Objectives: Chronic obstructive pulmonary disease(COPD) is an important cause of mortality in workers exposed to hazardous dust, such as crystalline silica or coal, and COPD is related to inflammation and oxidative stress in the lung. The aim of this study was to evaluate the association of oxidative stress and inflammation to COPD in retired workers exposed to mineral dust.

Methods: The levels of malondialdehyde(MDA) in EBC as biomarkers for oxidative stress and C-reactive protein(CRP) and lactate dehydrogenase(LD) as biomarkers for inflammation were measured in 107 male subjects(63 pneumoconiosis and 42 COPD subjects).

Results: Mean levels of EBC MDA(2.03 nmol/L vs. 4.65 nmol/L, p=0.010) and serum LD(170.3 U/L vs. 185.9 U/L, p=0.022) were significantly higher in subjects with COPD, but mean levels of serum CRP(p=0.469) did not show a statistical difference between the study groups. Level of EBC MDA was negatively correlated with %FEV1 predicted(r=-0.279, p=0.004) and %FEV1/FVC ratio(r=-0.397, p<0.001).

Conclusions: These results suggest that EBC is a useful biological matrix for investigation of respiratory oxidative stress. High levels of EBC MDA and serum LD are related to COPD in retired workers exposed to mineral dust.

키워드

Chronic obstructive pulmonary disease; C-reactive protein; exhaled breath condensate; lactate dehydrogenase; malondialdehyde
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