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The Genomic Landscape and Its Clinical Implications in Hepatocellular Carcinoma

대한간암학회지 2019년 19권 2호 p.97 ~ 107
 ( Yim Sun-Young ) - Korea University Medical Center Department of Internal Medicine

이주석 ( Lee Ju-Seog ) - University of Texas MD Anderson Cancer Center Department of Systems Biology and Cancer Biology

Abstract


The pathogenesis of hepatocellular carcinoma (HCC) is a complex process. During the last decade, advances in genomic technologies enabled delineation of the genomic landscape of HCC, resulting in the identification of the common underlying molecular alterations. The tumor microenvironment, regulated by inflammatory cells, including cancer cells, stromal tissues, and the surrounding extracellular matrix, has been extensively studied using molecular data. The integration of molecular, immunological, histopathological, and clinical findings has provided clues to uncover predictive biomarkers to enhance responses to novel therapies. Herein, we provide an overview of the current HCC genomic landscape, previously identified gene signatures that are used routinely to predict prognosis, and an immune-specific class of HCC. Since biomarker-driven treatment is still an unmet need in HCC management, translation of these discoveries into clinical practice will lead to personalized therapies and improve patient care, especially in the era of targeted and immunotherapies.

키워드

Advanced hepatocellular carcinoma; Sorafenib; Adverse event; Pancreatic pseudocyst; Pancreatitis
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