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Human Papillomavirus Serologic Profiles of Selected Filipinos with Head and Neck Squamous Cell Carcinoma

Journal of Pathology and Translational Medicine 2019년 53권 5호 p.273 ~ 279
 ( Albano Pia Marie ) - German Cancer Research Center Division of Molecular Diagnostics of Oncogenic Infections

 ( Salvador Christianne ) - Mariano Marcos Memorial Hospital and Medical Center Department of ENT Head and Neck Surgery
 ( Orosa Jose ) - Mariano Marcos Memorial Hospital and Medical Center Department of ENT Head and Neck Surgery
 ( Racelis Sheryl ) - Mariano Marcos Memorial Hospital and Medical Center Department of Pathology and Laboratories
 ( Leano Modesty ) - Mariano Marcos Memorial Hospital and Medical Center Department of Pathology and Laboratories
 ( Michel Angelika ) - German Cancer Research Center Division of Molecular Diagnostics of Oncogenic Infections
 ( Ramos John Donnie A. ) - University of Santo Tomas College of Science Department of Biology
 ( Holzinger Dana ) - German Cancer Research Center Division of Molecular Diagnostics of Oncogenic Infections
 ( Pawlita Michael ) - German Cancer Research Center Division of Molecular Diagnostics of Oncogenic Infections

Abstract


Background: The low prevalence of human papillomavirus (HPV) DNA and mRNA in biopsy samples of Filipinos with head and neck squamous cell carcinoma (HNSCC) has been reported previously. Here, the HPV serologic profiles of HNSCC cases were analyzed and associated with lifestyle and sexual practices.

Methods: Serum samples were collected between May 2012 and September 2013 from HNSCC patients (n = 22) in the northwest region of the Philippines, and age- and sex-matched clinically healthy controls. Antibodies to capsid and early oncoproteins of HPV16, 18, 31, 33, 45, 52, 58, 6, and 11 were analyzed using multiplex serology.

Results: Most of the cases were males with tumors of the oral cavity or larynx. Two of the cases tested positive for at least one of the early oncoproteins (E6, E7, E1, and/or E2) of HPV16, and 11 did not display reactivity to any HPV early or late oncoproteins. Of the controls, four tested positive for at least one of the HPV16 early oncoproteins, and 10 were non-reactive to all HPV types. Titers to HPV16 E6 or E7 of the seropositive cases and controls were considerably lower than those typically observed in economically developed countries.

Conclusions: The low HPV titers seen here are consistent with the results of molecular analyses for this population. Hence, the seropositivity of some of the HNSCC cases is likely an indication of prior exposure to the virus and not the presence of HPV-driven tumors.

키워드

HPV antibodies; Head and neck squamous cell carcinoma; Philippines; Multiplex serology
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