medric medric
[닫기]
잠시만 기다려 주세요. 로딩중입니다.

High Expression of Galectin-1, VEGF and Increased Microvessel Density Are Associated with MELF Pattern in Stage I-III Endometrioid Endometrial Adenocarcinoma

Journal of Pathology and Translational Medicine 2019년 53권 5호 p.280 ~ 288
 ( Zinovkin Dmitry Aleksandrovich ) - Gomel State Medical University Department of Pathology

 ( Achinovich Sergey Leonidovich ) - Gomel State Clinical Oncological Dispensary Department of Pathology
 ( Zubritskiy Mikhail Grigoryevich ) - Grodno Regional Clinical Bureau of Pathology Department of Pathology
 ( Whatmore Jacqueline Linda ) - University of Exeter Medical School Institute of Biomedical and Clinical Science
 ( Pranjol Md Zahidul Islam ) - Queen Mary University of London Barts and London School of Medicine and Dentistry William Harvey Research Institute

Abstract


Background: In this study, we investigate the expression of markers of angiogenesis and microvessel density (MVD) in cases of microcystic, elongated and fragmented (MELF) pattern, with its prognostic role in the survival of endometrioid endometrial adenocarcinomas (EA) patients.

Methods: In this study, 100 cases of EA, 49 cases with MELF pattern and 51 without, were immunohistochemically stained for galectin-1, vascular endothelial growth factor (VEGF), and MVD. Morphometry and statistical (univariate and multivariate) analyses were performed to assess overall survival (OS) and disease-free survival.

Results: The expression of VEGF (p<.001) and galectin-1 (p<.001), as well as MVD area (p<.001) and number of vessels/mm2 (p<.050), were significantly higher in the +MELF pattern group compared to the ?MELF group. A low negative correlation between MELF-pattern and the number of days of survival (p<.001, r=?0.47) was also found. A low positive correlation of MELF-pattern with galectin-1 expression (p<.001, r=0.39), area of vessels/mm2 (p<.001, r=0.36), outcome of EA (p<.001, r=0.42) and VEGF expression (p<.001, r=0.39) suggests potential pathological relevance of these factors in the prognosis of EA. A univariate survival analysis indicated a role for all parameters of survival. Multivariate Cox proportional hazard regression analysis revealed that only area of vessels/mm2 (hazard ratio [HR], 1.018; 95% confidence interval [CI], 1.002 to 1.033), galectin-1 (HR, 1.049; 95% CI, 1.025 to 1.074) and VEGF (HR, 1.049; 95% CI, 1.022 to 1.077) play key roles in OS.

Conclusions: This study reports an increase in MVD, VEGF and galectin-1 expression in EA with MELF pattern and suggests that MELF pattern, along with the angiogenic profile, may be a prognostic factor in EA.

키워드

Endometrioid endometrial carcinoma; MELF pattern; Galectin-1; Microvessel density; VEGF
원문 및 링크아웃 정보
 
등재저널 정보
KCI