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Long-Term Outcomes of Adult Lung Transplantation Recipients: A Single-Center Experience in South Korea

Tuberculosis and Respiratory Diseases 2019년 82권 4호 p.348 ~ 356
 ( Jo Kyung-Wook ) - University of Ulsan College of Medicine Asan Medical Center Division of Pulmonary and Critical Care Medicine

 ( Hong Sang-Bum ) - University of Ulsan College of Medicine Asan Medical Center Division of Pulmonary and Critical Care Medicine
 ( Kim Dong-Kwan ) - University of Ulsan College of Medicine Asan Medical Center Department of Thoracic and Cardiovascular Surgery
 ( Jung Sung-Ho ) - University of Ulsan College of Medicine Asan Medical Center Department of Thoracic and Cardiovascular Surgery
 ( Kim Hyeong-Ryul ) - University of Ulsan College of Medicine Asan Medical Center Department of Thoracic and Cardiovascular Surgery
최세훈 ( Choi Se-Hoon ) - University of Ulsan College of Medicine Asan Medical Center Department of Thoracic and Cardiovascular Surgery
 ( Lee Geun-Dong ) - University of Ulsan College of Medicine Asan Medical Center Department of Thoracic and Cardiovascular Surgery
 ( Lee Sang-Oh ) - University of Ulsan College of Medicine Asan Medical Center Department of Infectious Diseases
도경현 ( Do Kyung-Hyun ) - University of Ulsan College of Medicine Asan Medical Center Department of Radiology
채은진 ( Chae Eun-Jin ) - University of Ulsan College of Medicine Asan Medical Center Department of Radiology
 ( Choi In-Cheol ) - University of Ulsan College of Medicine Asan Medical Center Department of Anesthesiology and Pain Medicine
 ( Choi Dae-Kee ) - University of Ulsan College of Medicine Asan Medical Center Department of Anesthesiology and Pain Medicine
 ( Kim In-Ok ) - Asan Medical Center Organ Transplantation Center
 ( Park Seung-Il ) - University of Ulsan College of Medicine Asan Medical Center Department of Thoracic and Cardiovascular Surgery
 ( Shim Tae-Sun ) - University of Ulsan College of Medicine Asan Medical Center Division of Pulmonary and Critical Care Medicine

Abstract


Background: Recently, the number of lung transplants in South Korea has increased. However, the long-term outcome data is limited. In this study, we aimed to investigate the long-term outcomes of adult lung transplantation recipients.

Methods: Among the patients that underwent lung transplantation at a tertiary referral center in South Korea between 2008 and 2017, adults patient who underwent deceased-donor lung transplantation with available follow-up data were enrolled. Their medical records were retrospectively reviewed.

Results: Through eligibility screening, we identified 60 adult patients that underwent lung (n=51) or heart-lung transplantation (n=9) during the observation period. Idiopathic pulmonary fibrosis (46.7%, 28/60) was the most frequent cause of lung transplantation. For all the 60 patients, the median follow-up duration for post-transplantation was 2.6 years (range, 0.01?7.6). During the post-transplantation follow-up period, 19 patients (31.7%) died at a median duration of 194 days. The survival rates were 75.5%, 67.6%, and 61.8% at 1 year, 3 years, and 5 years, respectively. Out of the 60 patients, 8 (13.3%) were diagnosed with chronic lung allograft dysfunction (CLAD), after a mean duration of 3.3±2.8 years post-transplantation. The CLAD development rate was 0%, 17.7%, and 25.8% at 1 year, 3 years, and 5 years, respectively. The most common newly developed post-transplantation comorbidity was the chronic kidney disease (CKD; 54.0%), followed by diabetes mellitus (25.9%).

Conclusion: Among the adult lung transplantation recipients at a South Korea tertiary referral center, the long-term survival rates were favorable. The proportion of patients who developed CLAD was not substantial. CKD was the most common post-transplantation comorbidity.

키워드

Lung Transplantation; Survival; Chronic Lung Allograft Dysfunction; Chronic Kidney Disease
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