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Synthesis and Biological Activity of (2-Substituted-4-methylthiazol-5-yl) (4-substituted piperazin-1-yl)methanone Derivatives

대한화학회지 2014년 58권 1호 p.62 ~ 67
 ( Mhaske Pravin C. ) - S. P. Mandali’s Sir Parashurambahu College Department of Chemistry

 ( Shelke Shivaji H. ) - HPT Arts and RYK Science College Department of Chemistry
 ( Raundal Hemant N. ) - HPT Arts and RYK Science College Department of Chemistry
 ( Jadhav Rahul P. ) - HPT Arts and RYK Science College Department of Chemistry

Abstract


In the present study a novel series of (2-substituted-4-methylthiazol-5-yl)(4-substituted piperazin-1-yl)methanone derivatives were synthesized by reaction of 2-substituted-4-methylthiazole-5-carboxylic acid with N-substituted benzyl piperazine by using 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide hydrochloride (EDCl) and 1-hydroxybenzotriazole (HOBt) in DMF. All the newly synthesized compounds were characterized by spectral methods. The title compounds were screened for in vitro antibacterial activity. Most of the compounds show moderate to good antimicrobial activity.

키워드

Thiazole; Piperazine; EDCl-HOBt; Antimicrobial activity
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