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One-Pot and Green Procedure for the Synthesis of 3,4-Dihydropyrimidin-2(1H)-(thio)ones Using ZnO Nanoparticles as a Solid Acid Catalyst

대한화학회지 2014년 58권 5호 p.445 ~ 449
 ( Hassanpour Akbar ) - Islamic Azad University Marand Branch Department of Chemistry

 ( Abolhasan Jafar ) - Islamic Azad University Tabriz Branch Department of Chemistry
 ( Khanmiri Rahim Hosseinzadeh ) - Shahid Beheshti University Department of Chemistry


A convenient and efficient method has been developed for the one-pot synthesis of dihydropyrimidinones (DHPMs) compounds. Dihydropyrimidinone derivatives were synthesized in good yields using ethyl acetoacetate, aldehyde (aromatic and aliphatic) and urea or thiourea in the presence of ZnO nanoparticles as a catalyst in H2O as solvent at 80 oC. This green chemistry procedure applied to the Biginelli reaction using ZnO nanoparticles as catalyst and illustrated as a rapid preparation of DHPMs in water as solvent. The products were identified by physical data (mp) by comparison with those reported in the literatures.


Biginelli reaction; Multicomponent reaction; ZnO nanoparticles; Dihydropyrimidinone
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