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Synthesis and Characterization of Novel Oxadiazole Derivatives from Benzimidazole

대한화학회지 2014년 58권 5호 p.450 ~ 455
 ( Vishwanathan Balasubramanaya ) - JSS University JSS College of Pharmacy Department of Pharmaceutical Chemistry

 ( Gurupadayya Bannimath ) - JSS University JSS College of Pharmacy Department of Pharmaceutical Chemistry

Abstract


In the present study, a series of novel N-(1H-benzo[d]imidazol-2-yl)methyl-5-[(hetero)aryl-1,3,4-oxadiazol-2- yl]methanamine (4a-4j) were efficiently synthesized. Condensation of hydrazide derivative 3 with various carboxylic acid derivatives yielded N-[(1H-benzo[d]imidazol-2-yl)methy](5-substituted-1,3,4-oxadiazol-2-yl)methanamine (4a-4j) and compound 5-{[(1H-benzo[d]imidazol-2-yl)methylamino]methyl}-1,3,4-oxadiazole-2-thiol (4k) was obtained on treating hydrazide 3 with carbon disulfide. All the newly synthesized analogues were characterized by IR, 1H NMR, 13C NMR and mass spectral data.

키워드

Benzimidazole; Oxadiazole
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