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Synthesis and Antimicrobial Screening of Pyrimidine Annulated Dihydropyrano[2, 3-c]pyrazole Derivatives

대한화학회지 2018년 62권 2호 p.87 ~ 92
 ( Hegde Hemant ) - Manipal Institute of Technology Department of Chemistry

 ( Ahn Chul-Jin ) - Changwon National University Department of Chemistry
 ( Waribam Preeti ) - Manipal Institute of Technology Department of Chemistry
 ( Shetty Nitinkumar S. ) - Manipal Institute of Technology Department of Chemistry

Abstract


A series of pyrimidine annulated dihydropyrano[2, 3-c]pyrazole derivatives were synthesized and screened for their antimicrobial activity. The precursor, dihydropyrano[2, 3-c]pyrazole was synthesised under catalyst free condition using PEG-400 as reaction medium which facilitated improved yield compared to base catalyzed reaction. Wide scope of substrates, simple workup procedure and high yield even in the absence of catalyst are the major highlights of the protocol. Dihydropyrano[ 2, 3-c]pyrazoles on condensation with formic acid formed pyrimidine annulated dihydropyrano[2, 3-c]pyrazole derivatives. All the products are characterized using FTIR, 1H-NMR and 13C-NMR spectroscopic techniques. The molecules have shown good to moderate activity as antimicrobial agents when compared to the standard drug ciprofloxacin.

키워드

Dihydropyrano[2, 3-c]pyrazole; PEG-400; Green medium; Annulation; Antimicrobial agents
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