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Result Patterns and Characteristics of HBeAg and HBV DNA in Patients with Chronic Hepatitis B

Laboratory Medicine Online 2019년 9권 4호 p.210 ~ 217
 ( Choi Eun-Jin ) - Jangwon Medical Foundation U2 Clinical Laboratories Department of Laboratory Medicine

 ( Kim Jae-Han ) - Jangwon Medical Foundation U2 Clinical Laboratories Department of Laboratory Medicine
 ( Han Mi-Soon ) - Jangwon Medical Foundation U2 Clinical Laboratories Department of Laboratory Medicine

Abstract


Background: Discrepancies in the results between hepatitis B e-antigen (HBeAg) and hepatitis B virus (HBV) DNA levels pose difficulties in the management of chronic hepatitis B (CHB). This study aims to better understand the different phases of CHB and to detect additional meaningful parameters for CHB patients.

Methods: We collected datasets of HBeAg and HBV DNA levels measured during 2016 and the follow-up results for CHB patients for past 3 years. We analyzed the collected data by applying the definitions of CHB clinical phase and compared the results of semi-quantitative and quantitative HBeAg assays.

Results: About 55% of 2,291 result pairs from CHB patients showed qualitative agreement between HBeAg and HBV DNA results. HBeAg (?) CHB was reported in 16.49%, while hepatitis B surface antigen (HBsAg) loss occurred in 0.18% among 1,146 patients annually. HBeAg reversion occurred in 2.74% of 839 patients that experienced HBeAg seroconversion. Patients with HBeAg (+) and HBV DNA (?) showed statistically significant differences in the levels and percentage abnormality of alanine aminotransferase (ALT) based on whether HBV DNA was ‘Target not detected’ or ‘Detected,
Conclusions: This study reveals clinically important result patterns during the different phases of CHB. ALT level and percentage abnormality were significantly different based on HBV DNA status in HBeAg (+) and HBV DNA (?) patients. We suggest that clinical laboratories should report ‘HBV DNA (?)’ separately as ‘Target not detected’ and ‘Detected,

키워드

HBeAg; Viral DNA; Chronic hepatitis B; Alanine aminotransferase; HBsAg
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