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Acute Monoblastic Leukemia with t(11;17)(q23;q21): Fusion of the KMT2A(MLL) and MLLT6(AF17) Genes

Laboratory Medicine Online 2019년 9권 4호 p.258 ~ 262
 ( Park Cheon-Gang ) - Daegu Catholic University School of Medicine Department of Laboratory Medicine

 ( Mun Seon-Ho ) - Daegu Catholic University School of Medicine Department of Laboratory Medicine
이아진 ( Lee A-Jin ) - Daegu Catholic University School of Medicine Department of Laboratory Medicine
전창호 ( Jeon Chang-Ho ) - Daegu Catholic University School of Medicine Department of Laboratory Medicine
 ( Suh Hun-Suk ) - Daegu Catholic University School of Medicine Department of Laboratory Medicine
김상경 ( Kim Sang-Gyung ) - Daegu Catholic University School of Medicine Department of Laboratory Medicine

Abstract


The KMT2A (formerly MLL) gene is associated with at least 10% of all cases of acute leukemia. More than 80 translocation partner genes of KMT2A have been discovered to date, six of which have been identified on the long arm of chromosome 17. Among these, the MLLT6 (formerly AF17) gene is located at 17q12 and fuses with the KMT2A gene in rare cases of acute leukemia. We report here a case of AML with a KMT2A/MLLT6 fusion that was confirmed using molecular genetic methods. According to a literature review, this is the first reported case of AML with a KMT2A/MLLT6 fusion in Korea.

키워드

Acute monoblastic leukemia; AML; KMT2A; MLL; MLLT6
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