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Recent Advances in Anti-Aging Medicine

Korean Journal of Family Medicine 2019년 40권 5호 p.289 ~ 296
 ( Son Da-Hye ) - Yonsei University College of Medicine Department of Family Medicine

 ( Park Woo-Jin ) - Catholic University College of Medicine Incheon St. Mary’s Hospital Department of Internal Medicine
 ( Lee Yong-Jae ) - Yonsei University College of Medicine Department of Family Medicine

Abstract


A rapidly aging population in Korea has led to increased attention in the field of anti-aging medicine. The purpose of anti-aging medicine is to slow, stop, or reverse the aging process and its associated effects, such as disability and frailty. Anti-aging medicine is emerging as a growing industry, but many supplements or protocols are available that do not have scientific evidence to support their claims. In this review, the mechanisms of action and the clinical implications of anti-aging interventions were examined and explained. Calorie restriction mimetics define compounds that imitate the outcome of calorie restriction, including an activator of AMP protein kinase (metformin), inhibitor of growth hormone/insulin-like growth factor-1 axis (pegvisomant), inhibitor of mammalian target of rapamycin (rapamycin), and activator of the sirtuin pathway (resveratrol). Hormonal replacement has also been widely used in the elderly population to improve their quality of life. Manipulating healthy gut microbiota through prebiotic/probiotics or fecal microbiota transplantation has significant potential in anti-aging medicine. Vitamin D is expected to be a primary anti-aging medicine in the near future due to its numerous positive effects in the elderly population.

키워드

Aging; Hormone Replacement Therapy; Calorie Restriction; Vitamin D
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