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Perirenal fat thickness is associated with metabolic risk factors in patients with chronic kidney disease

Kidney Research and Clinical Practice 2019년 38권 3호 p.365 ~ 372
 ( D’Marco Luis ) - Consorci Sanitari del Garraf Servicio de Nefrologia

 ( Salazar Juan ) - Universidad Simon Bolivar Facultad de Ciencias de la Salud
 ( Cortez Marie ) - Puerto Ordaz Clinic Advanced Unit of Renal Sonographic Diagnostics
 ( Salazar Maria ) - Puerto Ordaz Clinic Advanced Unit of Renal Sonographic Diagnostics
 ( Wettel Marjorie ) - Puerto Ordaz Clinic Advanced Unit of Renal Sonographic Diagnostics
 ( Lima-Martinez Marcos ) - Universidad de Oriente Department of Physiological Sciences
 ( Rojas Edward ) - State University of New Jersey
 ( Roque Willy ) - State University of New Jersey
 ( Bermudez Valmore ) - Universidad Simon Bolivar Facultad de Ciencias de la Salud

Abstract


Background: Adipose tissue accumulation in specific body compartments has been associated with diabetes, hypertension and dyslipidemia. Perirenal fat (PRF) may lead to have direct lipotoxic effects on renal function and intrarenal hydrostatic pressure. This study was undertaken to explore the association of PRF with cardiovascular risk factors and different stages of chronic kidney disease (CKD).

Methods: We studied 103 patients with CKD of different stages (1 to 5). PRF was measured by B-mode renal ultrasonography in the distal third between the cortex and the hepatic border and/or spleen.

Results: The PRF thickness was greater in CKD patients with impaired fasting glucose than in those with normal glucose levels (1.10 ± 0.40 cm vs. 0.85 ± 0.39 cm, P < 0.01). Patients in CKD stages 4 and 5 (glomerular filtration rate [GFR] < 30 mL/min/1.73 m2) had the highest PRF thickness. Serum triglyceride levels correlated positively with the PRF thickness; the PRF thickness was greater in patients with triglyceride levels ≥ 150 mg/dL (1.09 ± 0.40 cm vs. 0.86 ± 0.36 cm, P < 0.01). In patients with a GFR < 60 mL/min/1.73 m2, uric acid levels correlated positively with the PRF thickness (P < 0.05).

Conclusion: In CKD patients, the PRF thickness correlated significantly with metabolic risk factors that could affect kidney function.

키워드

Cardiovascular; Chronic kidney disease; Diabetes; Metabolic risk; Perirenal fat; Renal insufficiency
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