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랫트 뇌에서의 galectin-3의 검출

Expression of galectin-3 in rat brain

대한수의학회지 2004년 44권 1호 p.83 ~ 88
이유경/Lee, Yoo-Kyoung
강해은/우희종/Kang, Hae Eun/Woo, Hee Jong

Abstract

Galectin family, endogenous b-galactoside-binding animal lectins, is known for the role in cell differentiation, morphogenesis, apoptosis and tumorigenesis. Galectin-3, one of family member, has been studied for its role in cell differentiation and tumor metastasis, and for its expression on epithelial cells of colon and mast cells but not in brain. Several reports, however, suggest its expression in brain including as a prion binding protein. In this report we explored possibility of galectin-3 expression in brain tissue. With Western blot and RT-PCR with rat brain tissues, we could detect galectin-3 that was not shown by conventional immunohistochemistry. Our results indicated galectin-3 was expressed in brain, and substantiate the previous report on galecin-3 as a prion-related protein in brain.

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