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Peroxynitrite Scavenging Activity of Phloroglucinol from Ecklonia stolonifera

대한암예방학회지 2000년 5권 1호 p.1 ~ 6
정해영 ( Chung Hae-Young ) - 부산대학교 약학대학

 ( Choi Hye-Rhi ) - 부산대학교 약학대학
박혜진 ( Park Hye-Jin ) - 부경대학교 식품생명과학과
최재수 ( Choi Jae-Sue ) - 부경대학교 식품생명과학과
최원철 ( Choi Won-Chul ) - 부산대학교 자연과학대학 생물학과

Abstract


Peroxynitrite (ONOO-), formed by the reaction of superoxide (O2-) and nitric oxide (NO), is a cytotoxic species that can oxidize several cellular components such as proteins, lipids, and DNA. It has been implicated in diseases such as cancer, Alzheimer´s disease, rheumatoid arthritis, and atherosclerosis. Due to the lack of endogenous enzymes responsible for ONOO- inactivation, developing a specific ONOO- scavenger is considerably important. The aim of this study was to evaluate the ability of phloroglucinol isolated from E. stolonifera to scavenge ONOO- and to protect cells against ONOO-. Phloroglucinol was found to be as a potent ONOO- scavenger. The data demonstrated that phloroglucinol led to decrease ONOO- -mediated nitration of tyrosine through electron donation. Phloroglucinol provided cytoprotection from cell damage induced by ONOO-.

키워드

Peroxynitrite;scavenging activity;phloroglucinol;Nitrotyrosine;Cytoprotection;Smooth muscle cells
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