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KMID : 0032220180300030345
Annals of Dermatology
2018년 30권 3호 p.345 ~ p.347

Metastatic Cutaneous Duodenal Gastrointestinal Stromal Tumor: A Possible Clue to Multiple Metastases
 ( Kim Young-Jae ) - University of Ulsan College of Medicine Asan Medical Center Department of Dermatology

 ( Lee Woo-Jin ) - University of Ulsan College of Medicine Asan Medical Center Department of Dermatology
 ( Won Chong-Hyun ) - University of Ulsan College of Medicine Asan Medical Center Department of Dermatology
 ( Choi Jee-Ho ) - University of Ulsan College of Medicine Asan Medical Center Department of Dermatology
 ( Lee Mi-Woo ) - University of Ulsan College of Medicine Asan Medical Center Department of Dermatology
- Abstract -
We report a case of a 69-year-old man with metastatic cutaneous duodenal gastrointestinal stromal tumor, which led to find multiple metastases on orbital muscle and scalp. The patient presented with a rapidly growing chest nodule with mild tenderness. He underwent surgical resection for duodenal gastrointestinal stromal tumor and had been treated with imatinib for three years. Histopathological examination of the chest nodule was consistent with gastrointestinal stromal tumor. A brain magnetic resonance imaging of follow work-up revealed multiple metastases at the left superior rectus muscle and occipital scalp. Under the diagnosis with imatinib-resistant duodenal gastrointestinal stromal tumors, a second-line therapy with sunitinib was tried. After six weeks, his skin lesion was completely improved and other metastatic cancers showed a response of stable disease. This is the first reported case of a cutaneous metastasis from duodenal GIST. This report emphasizes the importance of a full-skin examination in patients with a medical history of gastrointestinal stromal tumor which leads to find multiple metastases.
- Key Words -

Duodenum, Gastrointestinal stromal tumors, Neoplasm metastasis, Skin
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