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Relative Risk and Clinical Severity Assessment in Patients with Non-Oral Route Organophosphate Poisoning Compared with Oral Route Poisoning

Yonsei Medical Journal 2018년 59권 8호 p.982 ~ 988
KMID : 0311120180590080982
 ( Jung Woo-Jin ) - Yonsei University Wonju College of Medicine Department of Emergency Medicine

 ( Yu Min-Heui ) - Yonsei University Wonju College of Medicine Center of Biomedical Data Science
 ( Lee Yoon-Suk ) - Yonsei University Wonju College of Medicine Department of Emergency Medicine
 ( Kim Hyun ) - Yonsei University Wonju College of Medicine Department of Emergency Medicine
 ( Cha Yong-Sung ) - Yonsei University Wonju College of Medicine Department of Emergency Medicine
 ( Park Kyung-Hye ) - Yonsei University Wonju College of Medicine Department of Medical Education

Abstract

Purpose: Organophosphates, commonly used in agricultural pesticides, pose high risks and incidences of poisoning. In the present study, we investigated the relative risk and clinical severity, including laboratory results, of non-oral route poisoning (NORP) patients, compared to oral route poisoning (ORP) patients.

Materials and Methods: A single institutional toxicology database registry was utilized to gain information on clinical laboratory results on organophosphate poisoning patients who visited the emergency department (ED) between January 2000 and October 2016. Clinical outcomes, such as mortality and complication rates, were compared using 1:2 propensity score matching in the total cohort.

Results: Among a total of 273 patients in our study, 34 experienced NORP. After 1:2 propensity score matching, rates of respiratory complications and mortality were higher in the ORP group than in the NORP group. However, there was no difference in hospitalization time and time spent in the intensive care unit between the two groups. Compared with ORP patients after matching, the relative risk of mortality in NORP patients was 0.34, and the risk of respiratory distress was 0.47. The mean level of pseudocholinesterase was significantly higher in the NORP group than in the ORP group, while recovery rates were similar between the two groups.

Conclusion: Although the majority of NORP patients were admitted to the ED with unintentional poisoning and the relative risk of NORP was lower than that for ORP, we concluded that NORP is as critical as ORP. Considerable medical observation and intensive therapeutic approaches are also needed for NORP patients.
KeyWords

Organophosphate, cholinesterase, propensity score
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