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대장 및 직장암 환자에서 DNA Ploidy 및 증식능과 기존의 예후인자와의 상관관계 분석

Analysis of Correlation between DNA Ploidy and Proliferative Activity with Previous Prognostic Parameter of Colorectal Carcinoma

대한대장항문학회지 1996년 12권 1호 p.137 ~ 148
김상철 ( Kim Sang-Chul ) - 연세대학교 원주의과대학 외과학교실

김대성 ( Kim Dae-Sung ) - 연세대학교 원주의과대학 외과학교실
노병선 ( Rhoe Byung-Sun ) - 연세대학교 원주의과대학 외과학교실
윤광수 ( Yoon Gwang-Soo ) - 연세대학교 원주의과대학 외과학교실

Abstract


This study was designed to determine the reliability of DNA analysis in predicting outcome of patients with colorectal carcinoma and evaluated for the correlation of clinicopathologic parameters with DNA analysis as a prognostic factor of colorectal carcinoma. Eighty-five patients who underwent curative resection for colorectal carcinoma were examined for DNA ploidy, S-phase fraction and proliferative index by flow cytometry. 20 cases(23.6%) were DNA diploid, 65 cases(76.4%) were DNA aneuploid. The frequency of DNA aneuploid was noted higher as the poorer histologic grade, positive lymph node involvement and grossly ulceroinfiltrative pattern of tumor(p<0.05). The frequency of high S-phase fraction (S.P.F>20%), high proliferative index(P.I>30%) was noted higher as the poorer histologic grade, increased Duke’s stage
and positive lymph node involvement(p< 0.05). In patients with aneuplid with high S-phase fraction(S.P.F>20%) group, ratio of death, recurrence were significantly poor than those with aneuplid alone and diploid group(28.2% Vs 15.1% Vs 15%, p< 0.05). As the result of this study, we conclude that flow cytometric analysis of DNA content, histologic grade, Duke’s stave, lymph node involvement and gross pattern of tumor were significance prognostic factors in patients with colorectal carcinoma and provide more accurate assessment of outcome.

키워드

Colorectal Neoplasms;Flow Cytometry
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