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대장암에서의 nm23과 CD44 단백질 발현에 대한 면역조직학적 분석

Immunohistochemieal Study of Expression of nm23 and CD44 Protein in Colorectal cancer

대한대장항문학회지 1997년 13권 1호 p.15 ~ 21
신동일 ( Shin Dong-Il ) - 경희대학교 의과대학 외과학교실

이기형 ( Lee Kee-Hyung ) - 경희대학교 의과대학 외과학교실
윤충 ( Yoon Choong ) - 경희대학교 의과대학 외과학교실
이주희 ( Lee Joo-Hee ) - 경희대학교 의과대학 외과학교실

Abstract


Gene expression of the nm23 and CD44 has been investigated in number of tumors, in cluding colorectal cancer, breast cancer, and hepatocellular carcinoma. This study was conducted to clarify the association between nm23 and CD44 protein expression and metastatic potential in human colorectal cancer. To elucidate the role of the nm23 and
CD44 in human colorectal cancer, sections of formalin-fixed, paraffin-embeded tissue from 59 primary colorectal cancer were stained immunohistochemically against nm23 and CD44 proteins. Expression of the nm23 protein is not significantly correlate with Dukes’stage and recurrence. However, the expression of the CD44 protein is significantly higher in Dukes stage C as comparing with stage B.

키워드

Colorectal Neoplasms;nm23 H1 Protein;Recurrence
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