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대장 및 직장의 침윤성 선암종에서 AgNORs수와 환자의 생존율과의 관계

The Relationship of AgNORs to the Survival Rate of Patients with Invasive Colorectal Adenocarcinoma

대한대장항문학회지 1997년 13권 1호 p.43 ~ 50
강구 ( Kang Koo ) - 한림대학교 의과대학 병리학교실

남은숙 ( Nam Eun-Suk ) - 한림대학교 의과대학 병리학교실
신형식 ( Shin Hyung-Sik ) - 한림대학교 의과대학 병리학교실
김순란 ( Kim Soon-Ran ) - 한림대학교 의과대학 병리학교실
박영의 ( Park Young-Euy ) - 한림대학교 의과대학 병리학교실
이재정 ( Lee Jae-Jung ) - 한림대학교 의과대학 외과학교실
박철재 ( Park Chul-Jae ) - 한림대학교 의과대학 외과학교실
이민철 ( Lee Min-Chul ) - 단국대학교 의과대학 병리학교실

Abstract


Nucleolar organizer regions(NORs) are argyrophilic and have a loops of DNA that tran scribes to ribosomal RNA by RNA Polymerase I and are involved in formation of nucleolus. They are used in measuring proliferative activity of cells. Mean AgNORs count is increased or large and NORs are irregular in shape in malignant tumors. To examine the relationship of AgNORs to the survival rate of the patients with invasive colorectal adenocarcinoma, we counted mean AgNORs in 200 tumor cells and mean AgNORs#(mean AgNORs in counting AgNORs of the upper 40 nuclei after sorting AgNORs counts of 200 cell nuclei in descending order) after AgNOR staining using 45 cases of formalin-fixed, paraffin-embedded tissue surgically excised at Kang-Dong Sacred heart hospital. The survival rates were not related to age, sex, locations, differentiation, mAgNORs and mAgNORs# except Dukes’stages. There were only statistical significances in AgNORs# between high and low age group(p=0.0001), and between colon and rectum(p=0.005). But it is known that there could be different results according to staining time, fixation and preservation of tissues, counting methods in measuring AgNORs. There might be clinical usefulness of AgNOR if more cases are examined together with better tissue processing and staining methods.

키워드

Colorectal Neoplasms;AgNORs
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