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대장 직장선암에서 EGFR 및 VEGF 발현에 대한 면역조직화학적 분석

Immunohistochemical Analysis of the EGFR and VEGF Expression in Human Colorectal Adenocarcinoma

대한대장항문학회지 1997년 13권 4호 p.547 ~ 556
이상혁 ( Lee Sang-Hyuk ) - 중앙대학교 의과대학 외과학교실

박성일 ( Park Sung-Il ) - 중앙대학교 의과대학 외과학교실
임현묵 ( Lim Hyun-Muk ) - 중앙대학교 의과대학 외과학교실
박성준 ( Park Sung-Jun ) - 중앙대학교 의과대학 외과학교실
차성재 ( Cha Sung-Jae ) - 중앙대학교 의과대학 외과학교실
박언섭 ( Park Eon-Sub ) - 중앙대학교 의과대학 병리학교실

Abstract


The EGFR has been proposed as a stimulator of cell growth in some neoplasms. The VEGF play an important role in angiogenesis of several tumors. This study aimed to determine the EGFR and VEGF expression in colorectal adenocarcinoma and to correlate the expression of these gene with variable prognostic factors. Significant relationship
was observed between the EGFR and histopathologic differentiation or lymph node involvement. But EGFR had no relation to depth of invasiveness or serum CEA level. On the other hand, VEGF had only relation to histopathologic differentiation. VEGF had no relation to lymph node involvement, depth of tumor invasiveness or serum CEA level. We conclude that EGFR expression in human colorectal adenocarcinoma was significantly associated with prognosis. But VEGF expression was not associated with prognosis. More studies are needed to determine whether EGFR expression is a clinically valuable prognostic factor.

키워드

Colorectal Neoplasms
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